疼痛、阿片类药物流行和抑郁症

English | 2024 | ISBN: 0197675220 | 200 pages | True EPUB | 7.58 MB

Long-term prescription opioid use occurs in a substantial proportion of new opioid users. Most concerning is that high risk patients with comorbid depression, anxiety, nicotine dependence, and substance use disorders, compared to patients without these factors, continue to be prescribed higher opioid doses for longer durations, and are more likely to receive opioids with high abuse potential. To understand this phenomenon, we must consider the relationships between pain, mental illness, substance use disorder and long-term prescription opioid use. While separate fields have investigated the bi-directional relationships between depression, pain, and long-term prescription opioid use independently of one another, there is no text which has brought together the complex interaction of all three together. Drawing on contributions from neuroscience, pain psychiatry, clinical epidemiology, pharmacoepidemiology, clinical trials and research on social determinants of health, Pain, the Opioid Epidemic, and Depression is the first book to integrate currently siloed areas of investigation and clinical knowledge. This book takes a comprehensive approach, from neurophysiology to epidemiology to clinical practice, and explains the processes driving maintenance of chronic pain, persistent depression, and long-term prescription opioid use, as well as taper and buprenorphine treatment for opioid use disorder. Readers will come to understand the central role of depression, other psychiatric disorders, and social determinants that contribute to pain management outcomes, the opioid epidemic, and our response to opioid dependence and opioid use disorder. By taking a multidisciplinary approach to compiling what is known about the relationships between pain, depression, other psychiatric disorders and opioids, this volume will be a valuable clinical resource for a range of healthcare and mental health professionals who encounter chronic pain and comorbid mood disorders, while also spawning new directions for researchers.

中文|2024|ISBN:0197675220|200页|True EPUB |7.58 MB长期处方阿片类药物使用在很大比例的新阿片类患者中发生。最令人担忧的是，与没有这些因素的患者相比，患有抑郁症、焦虑症、尼古丁依赖症和药物使用障碍的高危患者在更长的时间内继续服用更高的阿片类药物剂量，并且更有可能接受具有高滥用潜力的阿片样药物。为了理解这一现象，我们必须考虑疼痛、精神疾病、物质使用障碍和长期处方阿片类药物使用之间的关系。虽然不同的领域已经独立地研究了抑郁症、疼痛和长期处方阿片类药物使用之间的双向关系，但没有文本将这三者的复杂相互作用结合在一起。借鉴神经科学、疼痛精神病学、临床流行病学、药物流行病学、临床试验和健康社会决定因素研究的贡献，《疼痛、阿片类药物流行病和抑郁症》是第一本整合目前孤立的调查和临床知识领域的书。本书采用了一种全面的方法，从神经生理学到流行病学再到临床实践，并解释了驱动慢性疼痛、持续抑郁和长期处方阿片类药物使用的过程，以及阿片类物质使用障碍的减量和丁丙诺啡治疗。读者将了解抑郁症、其他精神疾病和社会决定因素的核心作用，这些因素有助于疼痛管理结果、阿片类药物流行以及我们对阿片类依赖和阿片类使用障碍的反应。通过采用多学科的方法来汇编已知的疼痛、抑郁、其他精神疾病和阿片类药物之间的关系，这本书将成为一系列遇到慢性疼痛和共病情绪障碍的医疗保健和心理健康专业人员的宝贵临床资源，同时也为研究人员开辟了新的方向。

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