抗菌素耐药性：影响研究结果的因素

English | 2024 | ISBN-10: 3031659856 | 469 pages| Epub PDF (True) | 49 MB

Antimicrobial resistance (AMR) is increasing globally at an incredible rate, and many infectious diseases have already reached an alarming stage of resistance to existing treatments. WHO reports that nearly1.27 million people currently die each year due to resistant infections, and AMR is projected to account for 10 million annual deaths globally by 2050. There is an urgent need for novel approaches to address this issue. Omics technologies are powerful research tools used extensively to study pathogen biology and the activity of microbial agents. These tools, paired with systems biology approaches, can provide novel insights into antimicrobial susceptibility and resistance, and aid in the development of new, more effective measures to combat resistant pathogens. This book provides a comprehensive overview of omics technologies to study pathogen biology, including proteomics, genomics, transcriptomics, metabolomics, and microbiome analysis, and the role of systems biology in developing strategies to combat resistant pathogens. It addresses environmental reservoirs and mobile genetic agents in AMR, host-pathogen interactions and physiology in the development of resistance, drug repurposing and development, and cutting-edge tools such as machine learning, AI for big data analysis, and genomic surveillance. The final section discusses future perspectives on omics-systems biology in AMR, and identifies opportunities for scientific collaboration in the global fight against antimicrobial resistance. This book serves as a comprehensive and accessible resource for researchers in academia and industry focused on immunology, drug development, biotechnology, and systems biology.

中文|2024|ISBN-10:3031659856|469页|Epub PDF（True）|49 MB抗菌素耐药性（AMR）在全球范围内以惊人的速度增长，许多传染病已经达到了对现有治疗方法产生耐药性的惊人阶段。世界卫生组织报告称，目前每年有近127万人死于耐药性感染，预计到2050年，AMR将导致全球每年1000万人死亡。迫切需要新的方法来解决这个问题。组学技术是广泛用于研究病原体生物学和微生物活性的强大研究工具。这些工具与系统生物学方法相结合，可以提供有关抗菌药物敏感性和耐药性的新见解，并有助于开发新的、更有效的措施来对抗耐药病原体。本书全面概述了用于研究病原体生物学的组学技术，包括蛋白质组学、基因组学、转录组学、代谢组学和微生物组分析，以及系统生物学在制定对抗耐药病原体的策略中的作用。它解决了AMR中的环境库和移动遗传因子、耐药性发展中的宿主-病原体相互作用和生理学、药物再利用和开发，以及机器学习、大数据分析人工智能和基因组监测等尖端工具。最后一节讨论了AMR中组学系统生物学的未来前景，并确定了在全球对抗抗菌素耐药性的科学合作机会。本书为学术界和工业界专注于免疫学、药物开发、生物技术和系统生物学的研究人员提供了一个全面且可访问的资源。

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