绘制RNA测序及其修饰的未来：生物学和医学的新时代

English | 2024 | ISBN: 0309706955 | 274 pages | True PDF EPUB | 20.56 MB

Concerted efforts to deepen understanding of RNA modifications and their role in living systems hold the potential to advance human health, improve crop yields, and address other pressing societal challenges. RNA, which carries the information encoded by DNA to the places where it is needed, is amazingly diverse and dynamic. RNA is processed and modified through natural biological pathways, giving rise to hundreds, in some cases thousands, of distinct RNA molecules for each gene, thereby diversifying genetic information. RNA modifications are known to be pivotal players in nearly all biological processes, and their dysregulation has been implicated in a wide range of human diseases and disorders. Yet, our knowledge of RNA modifications remains incomplete, hindered by current technological limitations. Existing methods cannot discover all RNA modifications, let alone comprehensively sequence them on every RNA molecule. Nonetheless, what is known about RNA modifications has already been leveraged in the development of vaccines that helped saved millions of lives worldwide during the COVID-19 pandemic. RNA modifications also have applications beyond health, for example, enhancing agricultural productivity. Charting a Future for Sequencing RNA and Its Modifications: A New Era for Biology and Medicine calls for a focused, large-scale effort to accelerate technological innovation to harness the full potential of RNA modifications to address pressing societal challenges in health, agriculture, and beyond. This report assesses the scientific and technological breakthroughs, workforce, and infrastructure needs to sequence RNA and its modifications, and ultimately understand the roles RNA modifications play in biological processes and disease. It proposes a roadmap of innovation that will make it possible for any RNA from any biological system to be sequenced end-to-end with all of its modifications - a capability that could lead to more personalized and targeted treatments and instigate transformative changes across various sectors beyond health and medicine.

英文| 2024 |国际标准图书编号：0309706955 | 274页|真PDF EPUB | 20.56 MB 共同努力加深对RNA修饰及其在生命系统中作用的理解，有可能促进人类健康，提高作物产量，并解决其他紧迫的社会挑战。RNA将DNA编码的信息携带到需要的地方，其多样性和动态性令人惊讶。RNA通过自然生物途径进行加工和修饰，为每个基因产生数百个，在某些情况下是数千个不同的RNA分子，从而使遗传信息多样化。众所周知，RNA修饰在几乎所有生物过程中都起着关键作用，它们的失调与多种人类疾病和障碍有关。然而，由于当前的技术限制，我们对RNA修饰的了解仍然不完整。现有的方法无法发现所有的RNA修饰，更不用说在每个RNA分子上对它们进行全面测序了。尽管如此，在新冠肺炎大流行期间，已知的RNA修饰已经被用于疫苗的开发，帮助拯救了全球数百万人的生命。RNA修饰也有健康以外的应用，例如提高农业生产力。绘制RNA测序及其修饰的未来：生物学和医学的新时代需要集中、大规模的努力来加速技术创新，以充分利用RNA修饰的潜力来应对健康、农业等领域的紧迫社会挑战。本报告评估了测序RNA及其修饰所需的科学技术突破、劳动力和基础设施，并最终了解RNA修饰在生物过程和疾病中的作用。它提出了一个创新路线图，使来自任何生物系统的任何RNA都有可能在经过所有修改后进行端到端测序，这一能力可能导致更个性化和更有针对性的治疗，并在健康和医学以外的各个领域引发变革。

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