脱细胞胞外基质：表征、制备和应用
The extracellular matrix (ECM) supports cells and regulates various cellular functions in our body. The native ECM promises to provide an excellent scaffold for regenerative medicine. In order to use the ECM as a scaffold in medicine, its cellular fractions need to be removed while retaining its structural and compositional properties. This process is called decellularization, and the resulting product is known as the decellularized extracellular matrix (dECM). This book focuses on the sources of dECM and its preparation, characterization techniques, fabrication, and applications in regenerative medicine and biological studies. Using this book, the reader will gain a good foundation in the field of ECM decellularization complemented with a broad overview of dECM characterization, ranging from structural observation and compositional assessment to immune responses against dECM and applications, ranging from microfabrication and 3D-printing to the application of tissue-derived dECM in vascular grafts and corneal tissue engineering etc. The book closes with a section dedicated to cultured cell dECM, a complementary technique of tissue-derived dECM preparation, for application in tissue engineering and regenerative medicine, addressing its use in stem cell differentiation and how it can help in the study of the tumor microenvironment as well as in clinical trials of peripheral nerve regeneration.
中文| 2019 |页码：366 | ISBN:1788014677 | PDF | 12.6 mb细胞外基质（ECM）支持细胞并调节我们体内的各种细胞功能。天然ECM有望为再生医学提供良好的支架。为了将ECM用作医学支架，需要去除其细胞部分，同时保持其结构和组成特性。这个过程被称为脱细胞化，由此产生的产物被称为去细胞细胞外基质（dECM）。本书重点介绍dECM的来源及其制备、表征技术、制造以及在再生医学和生物学研究中的应用。通过这本书，读者将在ECM脱细胞领域打下良好的基础，并对dECM的特征进行广泛的概述，从结构观察和成分评估到针对dECM的免疫反应和应用，从微细加工和3D打印到组织衍生dECM在血管移植物和角膜组织工程中的应用等。这本书最后有一节专门介绍了培养细胞dECM，这是一种组织衍生dEM制备的补充技术，用于组织工程和再生医学，解决了它在干细胞分化中的应用，以及它如何帮助研究肿瘤微环境和外周神经再生的临床试验。本站不对文件进行储存，仅提供文件链接，请自行下载，本站不对文件内容负责，请自行判断文件是否安全，如发现文件有侵权行为，请联系管理员删除。
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