癌症精确病理学：从基本概念到临床实践

English | 2025 | ISBN: 1032844868 | 243 pages | True PDF EPUB | 61.44 MB

Precision pathology of cancer is a new frontier—a systemic diagnostic approach to provide specific therapeutic targets and genetic and metabolic information for the treatment of patients. Not only are cancers extremely diverse, but there is also heterogenetic variation among patients with the same cancer; owing to differences in genetic makeup and metabolic levels, a drug may work in one patient but be toxic in another. This text covers both basic concepts (the role of the precision pathologist, ethical issues, molecular basis, tools used in precision pathology, and specimen procurement) and clinical practice (the precise genes/pathways, ongoing clinical trials, therapeutics, pharmacogenomics, pharmacoproteomics, and pharmacometabolomics) in precision pathology of cancer.

English | 2025 | ISBN:1032844868 | 243 pages | True PDF EPUB | 61.44 MB癌症的精确病理学是一种新的前沿系统诊断方法，为患者的治疗提供特定的治疗靶点以及遗传和代谢信息。癌症不仅极其多样，而且同一癌症患者之间也存在异质性变异；由于基因组成和代谢水平的差异，一种药物可能对一名患者有效，但对另一名患者有毒。本文涵盖了癌症精确病理学的基本概念（精确病理学家的作用、伦理问题、分子基础、精确病理学中使用的工具和标本采购）和临床实践（精确基因/途径、正在进行的临床试验、治疗学、药物基因组学、药物组学和药物代谢组学）。

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