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纤维生长因子,第2版

Xiaokun Li | 2024 | ISBN: 0443157936 | English | 1032 pages | PDF | 141 MB

Fibroblast growth factors (FGFs) are secreted protein ligands that act in a paracrine or endocrine fashion to carry out their pleiotropic functions in development, tissue homeostasis and metabolism. Especially in recent years, more and more attention has been paid to this super family. In the past 30 years, Prof. Xiaokun Li’s research team has been focused on the field of basic mechanism and bioengineering of FGFs in China. This book is the second version which collected research results of Li’s team from 2013 to 2018. All these 9 chapters spans reviews of FGFs, injury repair and regeneration, metabolism, structure and modification, signaling pathway and pharmacology, pharmaceutics and new materials, bioreactor and engineering as well as FGF/FGFR inhibitors and others. This work should be a helper primer to scientists and particularly young students entering the FGFs field with their eye toward basic research and application.

The book contains nine chapters, systematically introducing readers to FGF, in the fields of injury repair and regeneration, endocrinology and metabolism, structure and modification, pharmaceutics, pharmacology, FGF/FGFR inhibitor, engineering and new drug development.


Fibroblast growth factors (FGFs) 是一类分泌的蛋白质配体,通过旁分泌或内分泌方式执行其多效功能,在发育、组织稳态和代谢中发挥作用。近年来,对这一超级家族的关注越来越多。在过去30年里,夏昆李教授的研究团队一直专注于中国FGF的基础机制和生物工程领域。这本书是2013年至2018年间李教授团队研究成果的第二版收集整理。这9章涵盖了FGFs、损伤修复与再生、代谢、结构与修饰、信号通路及药理学、制药学与新材料、生物反应器与工程技术以及FGF/FGFR抑制剂及其他内容的综述。这本书应是帮助科学家尤其是进入FGFs领域的年轻学生,无论是基础研究还是应用研究。 书中包含九章,系统地向读者介绍了FGF在损伤修复与再生、内分泌学和代谢、结构与修饰、制药学、药理学、FGF/FGFR抑制剂、工程技术以及新药物开发等领域。
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