细胞渗透调节剂：从蛋白质折叠的伴侣到临床视角

English | 2024 | ASIN: ‎ B0D8NVM91G | 218 pages | True PDF,EPUB | 16.83 MB

The second edition of this book presents the role of osmolytes in human health and diseases. Some of the chapters deal about the possibility of the use of osmolytes as diagnostic biomarkers and potential drug design for neurodegenerative and other human diseases. Other chapters also include reviews on the role of osmolytes in cancer, metastasis, infectious diseases, metabolic disorders, immunological disorders, and tissue regeneration. Importantly, the book also contain recent updates on the role of naturally occurring osmolytes in protein folding pathway, protein stability, and their underlying mechanisms. The book also covers the aspects that osmolytes could promote conformational alterations of transcription factors that favor metastatic behavior. Potential of the osmolytes in the various process of vaccine development, including enhancing the efficacy, production, and purification steps are also succintly described. Towards the end, the book also elucidates the use of specific molecules for the prevention of toxic gain of functions and restoration of function to disease-causing mutant protein. This book is an invaluable asset for the researchers especially working in osmolyte biology and scientists involved in basic and clinical research particularly neurodegeneration, diabetes, cancer, and metabolic disorders.

本书的第二版介绍了渗透溶质在人类健康和疾病中的作用。其中一些章节讨论了渗透溶质作为诊断生物标志物的可能性，以及用于治疗神经退行性疾病和其他人类疾病的潜在药物设计。其他章节还包括关于渗透溶质在癌症、转移、感染性疾病、代谢紊乱、免疫系统紊乱和组织再生中角色的综述。值得一提的是，本书还包含自然产生的渗透溶质在蛋白质折叠途径、蛋白质稳定性及其相关机制方面的最新更新。此外，本书还涵盖了渗透溶质能够促进转录因子构象变化，从而有利于转移行为的可能性。书中还简要描述了渗透溶质在疫苗开发的各种过程中的潜在用途，包括提高效力、生产以及纯化步骤。在书的最后部分，还阐述了使用特定分子预防毒性功能增强和恢复致病突变蛋白质功能的方法。这本书对从事渗透溶质生物学研究的研究人员来说是一笔宝贵的财富，特别是神经退行性疾病、糖尿病、癌症和代谢紊乱的基础及临床研究领域。

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