癌症精准病理学：从基本概念到临床实践

English | 2025 | ISBN: 1032844868 | 243 pages | True PDF EPUB | 61.44 MB

Precision pathology of cancer is a new frontier—a systemic diagnostic approach to provide specific therapeutic targets and genetic and metabolic information for the treatment of patients. Not only are cancers extremely diverse, but there is also heterogenetic variation among patients with the same cancer; owing to differences in genetic makeup and metabolic levels, a drug may work in one patient but be toxic in another. This text covers both basic concepts (the role of the precision pathologist, ethical issues, molecular basis, tools used in precision pathology, and specimen procurement) and clinical practice (the precise genes/pathways, ongoing clinical trials, therapeutics, pharmacogenomics, pharmacoproteomics, and pharmacometabolomics) in precision pathology of cancer.

癌症的精准病理学是新的前沿——一种系统性的诊断方法，旨在为患者的治疗提供特定的治疗靶点和遗传及代谢信息。不仅癌症种类繁多，同一癌症患者之间还存在异质性变异；因为基因组成和代谢水平的不同，一种药物在一名患者身上有效而在另一名患者身上却可能有毒。本文涵盖了精准病理学（精准病理学家的角色、伦理问题、分子基础、用于精准病理学的工具以及样本采集）的基本概念，以及精准癌症病理学中的临床实践（精确的基因/途径、正在进行的临床试验、治疗、药理遗传学、药物蛋白质组学和药物代谢组学）。

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