纳米载体在药物递送中的脑部应用
This book presents nanoparticles as potential drug delivery carriers for overcoming the blood-brain barrier. The initial chapter of the book discusses complex brain disorders, the currently available therapies, and their limitations. The book discusses the potential applications of polymeric nanoparticles, lipid nanocarriers, liposomes, inorganic nanoparticles, dendrimers, and stimuli-responsive polymers for targeted brain drug delivery. Further, it evaluates the development and role of different cell lines and animal models in brain research. Towards the end, the book reviews challenges, safety, toxicity, regulatory aspects, future possibilities, and constraints in the clinical translation of nanocarrier systems to treat neurological disorders. The book as such provides valuable information to neuroscientists, and researchers working in pharmaceuticals, nanomedicine, drug delivery research, and nanotechnology.
这本书将纳米颗粒作为克服血脑屏障潜在的药物递送载体进行了介绍。书籍的第一章讨论了复杂性脑疾病，目前可用的疗法及其局限性。本书讨论了聚meric纳米颗粒、脂质纳米载体、脂质体、无机纳米颗粒、树状大分子以及响应型聚合物在靶向脑部药物递送中的潜在应用。此外，它评估了不同细胞系和动物模型在脑科学研究中的发展与作用。在书的结尾部分，书籍回顾了将纳米载体制品转化为治疗神经系统疾病临床的可能性、安全性和毒性、监管方面、未来可能性以及限制因素。总的来说，这本书为神经科学家及从事制药业、纳米医学、药物递送研究和纳米技术的研究人员提供了宝贵的信息。
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