可持续的全球健康系统和药物开发

English | 2024 | ISBN-10: 3031504143 | 276 pages| Epub PDF (True) | 71 MB

Strategic decision-making focusing on economics is the fundamental requirement to generate efficiency and improve productivity in any manufacturing environment. In the 21st century, the science of drug development is an established field that requires a dedicated and synergistic partnership between various subject matter experts. Unfortunately, pharmaceutical research is complicated, time-consuming, attritive, and costly, with development costs ranging from $4 billion to $11 billion per commercialized drug. There are more than 750 biotech and big pharma companies in the US that are developing new drug products for a vast number of therapeutic indications. Due to the high attrition rate in clinical trials, a small percentage of these drugs get commercialized. Still, a very high amount of resources are being spent on drug development from a societal perspective.

Despite being an economically intense activity, the current state of drug product development makes a limited effort to integrate economics into product design and development. For example, pharmaceutical scientists are excellent at a data-driven decision-making process that requires technical elements and a few strategic elements. However, there is minimal integration of financial valuation elements (commonly employed in other high-tech industries such as fine chemicals, automotive, aerospace, etc.) into pharmaceutical drug development. Unfortunately, this hurts the sustainability of the health system of which these products will be a part in the future.

战略性决策在任何制造环境中追求经济性是产生效率和提高生产力的 fundamental 要求。21 世纪，药物开发的科学已成为一个已建立的领域，需要各种专业知识专家之间的专门且互补的合作伙伴关系。不幸的是，制药研究复杂、耗时、具有吸引力低并且昂贵，商业化药物的研发成本从 40 亿美元到 110 亿美元不等。美国有超过 750 家生物技术和大药厂公司正在开发治疗多种疾病的新型药品产品。由于临床试验的高失败率，其中只有极小比例的这些药物最终会被商业化。然而，从社会角度看，仍然花费了大量资源用于药物开发。 尽管药物产品开发处于经济密集型活动状态，但目前尚未做出有限的努力来整合经济学因素到产品设计和开发中。例如，制药科学家在需要技术元素和少数战略元素的数据驱动决策过程中非常出色。然而，在制药药物开发中对财务估值要素（通常在其他高科技行业如精细化学品、汽车、航空航天等使用的常用方法）的整合很少。不幸的是，这损害了这些产品未来将纳入其中的健康系统可持续性。

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