PROTAC介导的蛋白降解：癌症治疗的一场 paradigm 转移

English | 2024 | ISBN: 9819750768 | 400 pages | True EPUB PDF | 38.4 MB

This book is a comprehensive coverage of the ubiquitin-proteasome system and its involvement in cancer progression, and the application of PROTACs in different types of cancer treatment. The book discusses a unique perspective and comprehensive knowledge of the potential of PROTACs to transform cancer therapies. It provides an overview of the history, mechanisms, chemistry, design considerations, and different technologies involved in PROTACs. Additionally, it explains the ubiquitin-proteasome system, its impact on various diseases, and the principles and mechanisms of UPS. The book also describes the chemistry and design aspects of PROTACs and their role in various types of cancers. Finally, it covers the pharmaceutics aspect of formulation design, global requirements, and toxicological aspects of PROTACs. This book is targeted at cancer researchers, medical oncologists, bioinformatics, computational biologists, pharmacologists, medicinal chemists, formulation scientists, regulatory authorities, and policy makers.

这本书涵盖了泛素-蛋白酶体系统及其在癌症进展中的作用，以及PROTACs在不同类型的癌症治疗中的应用。本书从独特视角和全面知识探讨了PROTACs改变癌症疗法的潜力。它概述了PROTACs的历史、机制、化学、设计考虑和技术。此外，还解释了泛素-蛋白酶体系统对各种疾病的影响以及UPS的原则和机制。该书还描述了PROTACs的化学和设计方面及其在不同类型的癌症中的作用。最后，它涵盖了PROTACs制剂设计的药理学方面、全球要求和毒性方面的内容。本书的目标群体是癌症研究人员、内科肿瘤学家、生物信息学专家、计算生物学家、药理学家、药物化学家、 formulation科学家、监管机构以及政策制定者。

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