结构生物学中的冷冻电子显微术：从结构见解到断层扫描和药物发现

English | 2024 | ISBN: 9781003326106 | 488 pages | True PDF | 48.36 MB

Cryo-electron microscopy, in combination with tomography, has emerged as a new technology for visualizing molecular structures at a resolution beyond even 1 Å. Using this technology has revealed the native molecular details of viruses, membranes, enzymes, ribosomes, and cells. This comprehensive volume brings together authoritative overviews of these methods from structural and biological perspectives. It is a must-have for researchers and graduate students, as well as those working in industry, primarily in the areas of biophysics, structural biology, crystallography, and genomics.

Key Features

• Focuses on the applications of cryo-EM to structural biology

• Documents the importance of cryo-EM/ET approaches in studying the structural determinants of cellular organelle and membrane protein biochemistry

• Reviews the applications of high-resolution structures of viruses

• Emphasizes structural insights of nuclear and gene machineries

• Includes a section focused entirely on the applications of cryo-EM/ET in drug discovery and therapeutic development

Cryo电子显微镜结合了断层摄影技术，已成为一种用于可视化分子结构的新技术，分辨率甚至超过了1Å。利用这项技术揭示了病毒、膜、酶、核糖体和细胞的天然分子细节。这本全面的书籍汇集了从结构和生物视角对这些方法的权威概述。它对于研究人员和研究生以及在工业领域工作的人员来说都是必备之选，主要集中在生物物理、结构生物学、晶体学和基因组学等领域。 关键特点 • 专注于cryo-EM在结构生物学中的应用 • 记录了cryo-EM/ET方法在研究细胞器和膜蛋白生化结构的重要性 • 概述了病毒高分辨率结构的应用 • 强调对核和基因机器的结构性洞察 • 包含一个完全专注于cryo-EM/ET在药物发现与治疗开发中的应用部分

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