心血管-代谢疾病中的氧化应激

English | 2024 | ISBN: 3031621301 | 310 Pages | PDF EPUB (True) | 31 MB

The book dissects the role of oxidative stress in the pathogenesis of the leading causes of global morbidity and mortality, i.e. cardiovascular and metabolic diseases. The chapters discuss topics related to the role reactive oxygen species (ROS) play in hypertension, atherosclerosis, diabetes, obesity and related pathologies. One chapter discusses the clinical efficacy and safety considerations of GLP-1 receptor agonists and SGLT-2 inhibitors in obesity management and the associated cardiovascular complications. Another chapter discusses the context-dependent roles of matrix metalloproteases, and how their activity can be modulated and utilized for the development of improved drugs for cardiometabolic diseases. Moreover, how ROS and aging interplay to precipitate cardiovasculo-metabolic disease is discussed and highlighted. Similarly, how sex and sepsis interplay in the context of cardiorenal disease is teased out in one of the chapters. Preventive measures that can abrogate ROS-induced cardiovasclo-metabolic disease are discussed and clarified in the hope of reducing such a debilitating battery of diseases. Another chapter is fully dedicated to the roles of ROS in atherosclerosis, while another chapter deals with mechanisms and effect of ROS on various phenotypes of adipose tissues in the context of cardiovasculo-metabolic disease. A chapter also discusses the link between traumatic brain injury (TBI) and cardiovascular impairments, and how ROS plays a significant role in TBI-induced cardiovascular disease. A section dedicated to antioxidants as potential therapy is also included. Given the complexity of the mechanisms implicated in ROS-modulated responses, it remains challenging to assert a conclusive argument and pre-determined regimen for incorporating antioxidants into conventional therapies. In all of the chapters, the molecular, cellular, genetic, and pharmacological mechanisms implicated are covered from an applied science perspective.

这本书剖析了氧化应激在导致全球发病率和死亡率的主要疾病——心血管和代谢性疾病中的作用。章节讨论了活性氧（ROS）在高血压、动脉硬化、糖尿病、肥胖及其相关病理状态中的角色等相关话题。其中一章探讨了GLP-1受体激动剂和SGLT-2抑制剂在管理肥胖以及由此引发的与心血管并发症相关的临床有效性和安全性考虑。另一章讨论了基质金属蛋白酶的依赖于上下文的作用，如何调节其活性并利用它们来开发用于改善心脏代谢疾病的新药物。此外，还探讨了ROS与衰老之间如何相互作用以诱发心血管和代谢性疾病，并加以强调。同样地，在一个章节中探讨了性别和感染（sepsis）在心脏病和肾脏病上下文中的相互作用。书中讨论了可以消除由氧化应激引起的心血管-代谢疾病预防措施，希望减少这种令人衰弱的疾病的组合。还有一章专门探讨ROS在动脉粥样硬化中的角色，另一章则涵盖了心血管代谢疾病背景下的各种脂肪组织表型的相关机制和ROS对它们的影响。章节中也讨论了创伤性脑损伤（TBI）与心血管功能障碍之间的关系以及ROS在其引起的血管疾病中所起的作用。还包括一个关于抗氧化剂作为潜在疗法的章节。鉴于涉及ROS调节反应机制中的复杂性，将抗氧化剂整合到常规治疗中得出明确论点和预定方案仍然是具有挑战性的。在所有章节中，从应用科学的角度涵盖了涉及的分子、细胞、遗传学和药物动力学机制。

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