药物化学实践，第三版

English | 982 pages | Academic Press; 3 edition (August 7, 2008) | 0123741947 | PDF | 27.31 Mb

The Practice of Medicinal Chemistry fills a gap in the list of available medicinal chemistry literature. It is a single-volume source on the practical aspects of medicinal chemistry. Considered ""the Bible"" by medicinal chemists, the book emphasizes the methods that chemists use to conduct their research and design new drug entities. It serves as a practical handbook about the drug discovery process, from conception of the molecules to drug production.

The first part of the book covers the background of the subject matter, which includes the definition and history of medicinal chemistry, the measurement of biological activities, and the main phases of drug activity. The second part of the book presents the road to discovering a new lead compound and creating a working hypothesis. The main parts of the book discuss the optimization of the lead compound in terms of potency, selectivity, and safety.

The Practice of Medicinal Chemistry can be considered a ""first-read"" or ""bedside book"" for readers who are embarking on a career in medicinal chemistry.

《药物化学实践》填补了可用药物化学文献列表中的一个空白。它是关于药物化学实际方面的单卷资料来源。被认为是药物化学家的“圣经”，该书强调了化学家用来进行研究和设计新药物实体的方法。它作为一本手册，讲述了从分子构想到药品生产的过程。 这本书的第一部分涵盖了主题的背景知识，包括药物化学的定义和历史、生物活性测量以及药物活性的主要阶段。第二部分展示了发现一种新的先导化合物并建立工作假设的道路。本书的主要部分讨论了提高先导化合物效能性、选择性和安全性的优化问题。 《药物化学实践》可以被看作是对即将投身于药物化学事业的读者而言的一本“首读”书或一本床边书。

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