病毒性肿瘤学：基本科学和临床应用

English | 2009 | 491 Pages | ISBN: 047037991X | PDF | 4 MB

A comprehensive look at the latest research findings and clinical applications of oncogenic virusesWritten by a panel of academic experts, Viral Oncology is the first self-contained and comprehensive book to present both scientific and clinical information on viruses linked to some of the most important human cancers. Readers can turn to this book for the most in-depth and up-to-date coverage of: HPV-associated cancers; molecular events associated with HPV-induced human cancer; the role of the HPV E6 oncoprotein in malignant progression; virus association with brain tumors; involvement of the polyomavirus JCV in colorectal cancer; possibleassociation of BKV with prostate cancer; oncogenic transformation bypolyomavirus large T antigen; SV40 and human cancer; SV40 and mesothelioma; molecular immunology of hepatitis B–associated viral cancer; hepatitis B vaccine and hepatocellular carcinoma; pathogenesis of acute and chronic hepatitis Cvirus infection; molecular mechanisms of hepatitis C virus-induced cellulartransformation; clinical aspects of HTLV-1 associated cancer; oncogenic potential of the HTLV-1 tax protein; HIV-associated malignancy; HIV-related lymphoma; biology and epidemiology of HHV-8; the role of KSHV in pathogenesis of Kaposi'ssarcoma; molecular pathobiology of EBV infection; and EBV as a pathogen.Several chapters are devoted to the basic science of oncogenic viruses for thestudy of their pathogenesis, drug development, and employment of viral vectorsfor vaccine and gene therapy. The book also includes complementary clinically based chapters describing natural courses and treatments. Additionally, bonusclinical materials are embedded within chapters and an easy-to-use indexcompletes the book.Viral Oncology is an essential resource for clinical and research oncologists in medical facilities and biological research laboratories; clinicians and scientists working in related biomedical areas

《病毒性肿瘤学》是一本由学术专家团队撰写的、全面而详尽的书籍，它首次系统地展示了与人类最重大癌症相关的病毒的科学和临床信息。读者可以在这本书中找到关于人乳头瘤病毒感染引起的癌症、HPV诱导的人类癌症分子事件的相关内容；HPV E6原癌蛋白在恶性进展中的作用；病毒与脑肿瘤的关系；聚瘤病毒JC与结直肠癌的关联；BK病毒可能与前列腺癌有关的内容；由多瘤病毒大T抗原引发的致癌性转化；SV40与人类癌症以及间皮瘤的关系；乙肝相关病毒致癌学的基础免疫学研究；乙肝疫苗与肝细胞癌的关系；乙型肝炎病毒感染引起的急性和慢性肝炎的病因机制；HBV感染诱导的细胞转化的分子机制；HTLV-1相关肿瘤的临床特征；HTLV-1税蛋白的致癌潜力；HIV相关的恶性肿瘤及淋巴瘤；HHV-8病毒的生物学和流行病学研究；KSHV在Kaposi’s 肉瘤发病机制中的作用；EB病毒感染的基础病理生理学研究以及EB病毒作为病原体的功能，几章内容专门用于研究其致病过程、药物开发及病毒载体的应用。此外，还有与临床相关的章节描述了疾病的自然进程和治疗方式，并嵌入了一些额外的临床资料以供参考使用。最后，附有易用的索引，使整本书得以完善。《病毒性肿瘤学》是医学机构和生物研究实验室的临床医生及科研人员不可或缺的参考资料，也是相关生物医学领域工作的专业人员的重要工具书。

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