晶体工程中超分子合成子及其药理性质的supramolecular synthons in crystal engineering of pharmaceutical properties

English | 2024 | ISBN: 9781003260073 | 199 pages | True PDF | 49.79 MB

This comprehensive resource skillfully consolidates crystal engineering, the design of organic solids, and supramolecular synthons (i.e., structural hydrogen bond units) to achieve desired pharmaceutical properties, including solubility, dissolution, bioavailability, permeability, particle size, tableting, hydration, and mechanical strength. Covering 30 years of crystal engineering developments and pharmaceutical applications, this book will be a single and complete resource for supramolecular and structural chemists, the crystal engineering community, pharmaceutical scientists, and industrial researchers.

Key Features

Covers the fundamentals of crystal engineering and supramolecular synthons. Details the challenges of low solubility and low permeability facing oral drug formulations. Explains how heterosynthons provide a rational approach to address and implement solutions. Provides case studies from academic and industrial labs to walk the reader through the actual steps. Explores developments in the scale up and manufacture of crystal forms in pharmaceutical industry.

这本综合资源将晶体工程、有机固体的设计以及超分子合成子（即结构氢键单元）巧妙地整合起来，以实现所需的药理性质，包括溶解度、溶解性、生物利用度、渗透性、颗粒大小、压片、结晶水化和机械强度。涵盖30年晶体工程的发展与制药应用，这本著作将成为超分子化学家和结构化学家、晶体工程社群、制药科学家及工业研究者的单一且完整的资源。 关键特点 涵盖晶体工程和超分子合成子的基础知识。 详细描述口服药物制剂面临的低溶解性和低渗透性挑战。 解释如何异合成子提供一种理性的方法来应对并实施解决方案。 从学术实验室和工业实验室的案例中为读者展示实际步骤。 探索制药行业在晶体形式扩大生产与制造方面的发展。

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