精准癌症疗法，免疫学方法治疗淋巴瘤，第2卷

English | 2024 | ISBN: 1119824540 | 473 pages | PDF | 24.7 MB

Presents timely and authoritative information on the development of precision cancer therapies as applied to hematologic malignancies

The Precision Cancer Therapies series focuses on how to understand and translate fundamental basic science into information that can be directly applied to patients to advance care. Each volume of the series integrates the relevant biological concepts and principles necessary for translating this science to practitioners of this science.

Precision Cancer Therapies, Volume Two, focuses on sophisticated immunotherapies targeting cancers affecting the blood, bone marrow, and lymph nodes. Edited and authored by the foremost authorities in the field, this comprehensive reference text covers targeting of cell surface receptors, antibody-drug conjugates (ADC), targeting immune checkpoint, targeting macrophages, EBV-directed immunotherapies, tumor-associated antigens (TAA), and chimeric antigen receptor T-cells (CAR-T).

Divided into nine sections, Volume Two includes an overview of the history of immunotherapy development in cancer, as well as a concluding section addressing the mechanistic basis and role of immunomodulatory drugs, analytical tools to quantitate immune-mediated effects, and other topics in immunotherapy. Chapters on specific therapeutics or therapeutic classes include a basic explanation of the underlying pathway and target, the pharmacology of the drug/class, relevant preclinical and clinical data, and discussion of clinical management and potential predictive biomarkers of response. This book also

Delivers a definitive, state-of-the-art review of the relevant biology and its importance in the broader context of cancer biology Focuses on agents that mediate cell killing in lymphoma through a variety of immunologic mechanisms Covers FDA-approved drugs and their indications, as well as drugs currently in development Provides information on monotherapy and combination therapy, summary tables of trials, and discussion of toxicity and efficacy Includes boxed sections highlighting major unique points about the information in the chapter Precision Cancer Therapies, Volume Two: Immunologic Approaches for the Treatment of Lymphoid Malignancies, From Concept to Practice is an indispensable resource for medical, scientific, and allied medical professionals, advanced students, and interested general readers with background knowledge in the subject.

提供关于精准癌症疗法应用于血液恶性肿瘤发展的及时和权威信息

《精准癌症疗法》系列丛书关注如何理解和将基本的生物科学研究转化为可以直接应用于患者的科学信息，以推进护理。每卷系列都整合了必要的生物学概念和原则，以便把这项科学转换成该领域的专业人士。

《精准癌症疗法》，第二卷专注于针对影响血液、骨髓和淋巴结的癌症而开发的复杂免疫疗法。由这一领域最权威的专家编辑并撰写，这部全面参考书籍涵盖了细胞表面受体靶向、抗体药物偶联（ADC）、免疫检查点靶向、巨噬细胞靶向、EB病毒定向免疫疗法、肿瘤相关抗原（TAA）和嵌合抗原受体T细胞（CAR-T）。

分为九个部分，第二卷包括免疫治疗发展历史的概述，以及结尾部分探讨了免疫调节药物的基础机制及其在免疫疗法中的角色、量化免疫中介效应的分析工具以及其他一些免疫治疗主题。每一章节都包含特定疗法或疗法类别的基本解释，即基础途径和目标、药品/类别的药理学、相关临床前及临床数据，并讨论临床管理和潜在预测生物标志物。

本书还提供了一个全面而先进的生物学审查，重点介绍了淋巴瘤通过各种免疫机制进行细胞杀伤的疗法，涵盖FDA批准的药物及其用途，以及目前在开发中的药物。还包括总结表和对副作用与疗效的讨论。章节中配有强调关键独特信息的部分。

《精准癌症疗法》第二卷：淋巴瘤恶性肿瘤治疗的免疫学方法，从概念到实践，是医学、科学及相关医疗专业人员、高级学生和有该领域背景知识的一般读者不可或缺的资源。

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