酶和药物

English | 2024 | ISBN: 1786309394 | 216 pages | PDF | 10.69 MB

Enzyme dysfunction, an essential catalyst for the smooth running of biochemical reactions and the maintenance of vital processes, is at the root of many pathologies that have paved the way for the development of numerous drugs.

Aimed at pharmacists, biologists, biochemists, doctors, veterinarians, medicinal chemists and students from a wide range of disciplines, Enzymes and Drugs brings together, for the first time, extensive documentation highlighting the relationships between a large number of drugs and enzymes. The book also highlights new prospects for therapeutic discoveries offered by enzyme targeting.

Numerous applications have been developed thanks to strategies for studying enzyme inhibition or activation, as well as the development of allosteric effectors, presented with their advantages and disadvantages. Various rare diseases, known as "orphan" diseases, have resulted from enzyme deficiency or absence. For their treatment, the introduction of substitute enzymes has led to major therapeutic advances.

酶功能障碍是许多病理学的基础，它作为生物化学反应顺畅运行和维持重要过程的关键催化剂，是多种药物开发的根源。

本书面向广泛的药师、生物学家、生物化学家、医生、兽医、医药化学家和来自不同学科的学生，首次汇集了大量文档，详细说明了许多药物与酶之间的关系。此外，本书还强调了通过酶靶向所提供的新的治疗发现前景。

由于研究酶抑制或激活策略以及开发 allosteric 效应器所开发的多种应用，许多疾病已经得到控制。罕见病，即所谓的“孤儿” 疾病，通常是由于酶缺乏或缺失引起的。为了治疗这些病症，引入替代酶已经导致了重大治疗进展。

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