医学中的主要组织相容性复杂物（MHC/HLA）：个人回忆

English | 2024 | ISBN: 3031598652 | 119 Pages | PDF EPUB (True) | 25 MB

The reader will learn about the molecular structure of the encoded molecules and different aspects of their role in medicine, including organ transplantation, their link to autoimmune diseases, cancer immunity, resistance to infectious diseases, and other related scientific areas, such as population genetics. In particular, the book focusses on the impact of MHC/HLA altered expression in tumours and their relevance in cancer immune escape and immunotherapy. It contains a large number of original figures and photographs of pioneers in the field, who made seminal contributions. Each chapter is supported by relevant key publications and enriched with a personal account of the early research that has contributed to our current understanding of the role of the major histocompatibility complex.

读者将了解编码分子的分子结构以及它们在医学中的不同作用方面，包括器官移植、它们与自身免疫疾病的关系、癌症免疫力、对抗感染性疾病的能力以及其他相关科学领域，如种群遗传学。特别是，本书着重关注肿瘤中MHC/HLA表达改变的影响及其对癌症免疫逃逸和免疫治疗的相关性。它包含了大量的原创插图和照片，这些是该领域的先驱人物，他们做出了开创性的贡献。每一章都附有相关的关键出版物，并配以早期研究的个人经历，这一研究成果有助于我们目前对主要组织相容性复合体的理解。

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