镧系元素和其他过渡金属离子配合物和纳米颗粒在磁共振成像中的应用

English | 2024 | ISBN: 9781003374688 | 427 pages | True PDF | 33.94 MB

Since the development of the first clinical MRI contrast agent, Gd(DTPA) (or Magnevist®) in the early 1980s, another three linear and three macrocyclic (eg. Gd(DOTA) (Dotarem®) have been introduced in the clinic and inspired a huge number of researchers worldwide to perform preclinical research to obtain contrast agents for many kinds of clinical applications, which are described in this book. The most current research has been assembled here and can be used by the scientific community to continue increasing the relevance of metal-containing molecules and nanomaterials for MRI-based diagnosis and thus increase the practical use of these systems.

Presents the importance of metal-containing molecules and nanomaterials for MRI-based diagnosis and the practical use of these systems. Discusses the structure and dynamics of Ln-based contrast agents as well as computational studies related to these agents. Endorses and stimulates research in the vibrant field of biological inorganic chemistry. Reviews the most current research supporting the relevance of metal-containing molecules and nanomaterials for diagnosis and therapy. The authors are preeminent bioinorganic and medicinal inorganic chemists and review the most current research in this field.

自从早期20世纪80年代Gd(DTPA)（或Magnevist®）临床MRI对比剂的发展，到目前为止，已有三种线性和三种大环结构的对比剂被引入临床，激励了全球众多研究人员进行预临床研究以获取多种临床应用的对比剂。这些内容在这本书中进行了描述。最新的研究成果已经整合到这里，并可由科学界用于继续增加金属有机分子和纳米材料在基于MRI诊断中的相关性，从而进一步扩大这些系统的实用性。 强调并促进生物无机化学领域的蓬勃发展的研究。 讨论了Ln基对比剂的结构与动态特性，以及与之相关的计算研究。 支持并激发关于含有金属的分子和纳米材料在诊断和治疗中相关性的最新研究。 作者们是生物无机及有机药物化学领域的顶尖专家，并在此领域中提供了最新的研究成果。

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