癌症基因组学对临床医生而言

English | January 16, 2019 | ISBN-10: 0826168671 | 184 pages| Epub (True) | 6 MB

Cancer Genomics for the Clinician is a practical guide to cancer genomics and its application to cancer diagnosis and care. The book begins with a brief overview of the various types of genetic alterations that are encountered in cancer, followed by accessible and applicable information on next generation sequencing technology and bioinformatics; tumor heterogeneity; whole genome, exome, and transcriptome sequencing; epigenomics; and data analysis and interpretation. Each chapter provides essential explanations of concepts, terminology, and methods. Also included are tips for interpreting and analyzing molecular data, as well as a discussion of molecular predictors for targeted therapies covering hematologic malignancies and solid tumors. The final chapter explains the use of FDA-approved genomic-based targeted therapies for breast cancer, lung cancer, sarcomas, gastrointestinal cancers, urologic cancers, head and neck cancer, thyroid cancer, and many more. Assembled in an accessible format specifically designed for the non-expert, this book provides the clinical oncologist, early career practitioner, and trainee with an essential understanding of the molecular and genetic basis of cancer and the clinical aspects that have led to advancements in diagnosis and treatment. With this resource, physicians and trainees will increase their breadth of knowledge and be better equipped to educate patients and families who want to know more about their genetic predispositions to cancer and the targeted therapies that could be considered and prescribed.

《癌症基因组学对临床医生》是一本关于癌症基因组学及其在癌症诊断和护理中的应用的实用指南。本书从各种类型的遗传变异入手，介绍了在癌症中遇到的不同类型，并随后提供了一易于理解且适用的信息，包括基于下一代测序技术与生物信息学、肿瘤异质性、全基因组、外显子组和转录组测序、表观基因组学以及数据分析与解释。每个章节都提供了对概念、术语及方法的必要说明。本书还包含了分子数据分析和解释的技巧，以及针对血液恶性肿瘤和实体瘤靶向治疗的分子预测器的讨论。最后一章则阐明了FDA批准基于基因组学的靶向疗法在乳腺癌、肺癌、肉瘤、消化道癌症、泌尿系统癌症、头颈癌、甲状腺癌等领域的应用。 本书以其专为非专家设计的具体格式组装而成，使临床肿瘤学家、初出茅庐的专业人员以及训练生能够全面理解癌症分子和基因基础，并了解那些推动诊断与治疗进步的临床方面。借助此资源，医生和培训生将提升知识广度，更好地向希望了解更多关于遗传倾向及可考虑使用的靶向疗法的患者及其家庭成员进行教育。

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