心血管结局研究：临床医生指南——心血管流行病学和临床试验结局

English | PDF EPUB (True) | 2024 | 446 Pages | ISBN : 3031549597 | 27.4 MB

This book provides clinicians with the information needed to effectively interpret the literature from observational and interventional cardiovascular outcomes studies. The book begins by providing a historical context of cardiovascular epidemiology, followed by chapters addressing key concepts in the study of cardiovascular disease such as the types of cardiovascular outcomes studies, basic and evolving design and statistical considerations, current guidelines for reducing atherosclerotic cardiovascular disease risk, surrogate markers of cardiovascular disease, challenges in developing evidence-based recommendations for non-pharmacological interventions, an overview of the pharmaceutical development process, and a detailed discussion of the clinical evidence supporting several factors and their relationships with atherosclerotic cardiovascular disease (lipids, inflammation, hemostasis, heart rhythm, blood pressure, diabetes, obesity, and chronic kidney disease). Cardiovascular Outcomes Research is a must-have resource for physicians and other clinicians, residents, fellows, and medical students in cardiology, endocrinology, primary care, and health promotion and disease prevention.

这本书为临床医生提供了有效解读观察性和干预性心血管结果研究文献所需的信息。本书首先提供了一个心血管流行病学的历史背景，接着涵盖了一系列心血管疾病研究的关键概念，包括心血管结局研究的类型、基本和不断演变的设计与统计考量、降低动脉粥样硬化性心血管疾病风险的一般指导原则、心血管疾病的替代标志物、开发基于非药物干预的证据依据建议时面临的挑战、制药研发过程概述以及对几项因素与其与动脉粥样硬化性心血管疾病的关系进行详细讨论（包括脂质、炎症、凝血、心律、血压、糖尿病、肥胖和慢性肾病）。 心血管结果研究对于心脏病学、内分泌学、全科医学和健康促进及预防医学领域的医生、住院医师、研究生和医学生而言是一项必备资源。

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