神经母细胞瘤：发现与挑战

English | 2024 | ISBN-10: 303151291X | 229 pages| Epub PDF (True) | 28 MB

This book provides a state-of-the-art review of the biology, treatment, and other critical aspects of neuroblastoma, reflecting the dramatic advances that have been achieved in understanding and management. Topics are arranged according to the book’s dominant themes of the “seed” (tumor genomics, epigenetics, metabolism, and stem cells) and the “soil” (tumor microenvironment, adaptive and innate immunity, and exosomes) and how both of these influences can serve as rich targets for intervention, whether by targeted molecular therapy or immunotherapy. Therapeutic strategies that are currently in use or under consideration for the future are discussed in detail, with the focus on precision medicine. Further individual chapters are devoted to the biology and genetics of relapsed/refractory neuroblastoma and emerging methods of evaluating tumor burden. Finally, in keeping with the, albeit modest, increase in cure rates in high-risk disease, immune and cellular therapies are reviewed. This coverage of what is becoming a not-so-enigmatic tumor will appeal to a broad readership including both experimental oncologists and clinicians who care for patients with neuroblastoma.

这本书提供了神经母细胞瘤的生物、治疗及其他关键方面的一个先进综述，反映了我们在理解与管理该疾病方面取得的重大进展。内容按照本书的主题“种子”（肿瘤基因组学、表观遗传学、代谢和干细胞）和“土壤”（肿瘤微环境、适应性和固有免疫和外泌体）来安排，并展示了这两个因素如何可以作为干预的丰富靶点，无论是通过靶向分子疗法还是免疫疗法。详细讨论了目前正在使用或未来可能考虑的治疗策略，重点在于精准医疗。书中还为复发/难治性神经母细胞瘤的生物学和基因学以及肿瘤负担评估的新方法设立了专章。最后，在与高风险疾病治愈率略有增加保持一致的情况下，回顾了免疫和细胞疗法。对逐渐变得不那么神秘的这种肿瘤的覆盖范围将吸引包括实验性肿瘤学家在内的一系列读者群体，他们关心神经母细胞瘤患者。

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