《致命的继承：一个家族不幸揭露了致命的医疗 mystery》

Weaving his own moving family story with a sweeping history of cancer research, Lawrence Ingrassia delivers an intimate, gripping tale that sits at the intersection of memoir and medical thriller

Ingrassia lost his mother, two sisters, brother, and nephew to cancer—different cancers developing at different points throughout their lives. And while highly unusual, his family is not the only one to wonder whether their heartbreak is the result of unbelievable bad luck, or if there might be another explanation.

Through meticulous research and riveting storytelling, Ingrassia takes us from the 1960s—when Dr. Frederick Pei Li and Dr. Joseph Fraumeni Jr. first met, not yet knowing that they would help make a groundbreaking discovery that would affect cancer patients for decades to come—to present day, as Ingrassia and countless others continue to unpack and build upon Li and Fraumeni's initial discoveries, and to understand what this means for their families.

In the face of seemingly unbearable loss, Ingrassia holds onto hope. He urges us to "fight like Charlie," his nephew who battled cancer his entire life starting with a rare tumor in his cheek at the age of two—and to look toward the future, as gene sequencing, screening protocols, CRISPR gene editing, and other developing technologies may continue to extend lifespans and perhaps, one day, even offer cures.

将自己家族的悲惨故事与癌症研究的历史交织在一起，劳伦斯·英格里西亚（Lawrence Ingrassia）讲述了一部既亲密又扣人心弦的故事，它位于自传和医学惊悚小说之间。

英格里西亚失去了他的母亲、两个姐妹、兄弟以及侄子——不同类型的癌症在他们一生的不同阶段发展。虽然情况非常罕见，但他们的家庭并非唯一一个好奇自己的痛苦是否源于不可思议的不幸命运，或者或许还有其他解释。

通过详尽的研究和扣人心弦的故事叙述，英格里西亚带领我们从1960年代——当弗雷德里克·皮奥利博士（Dr. Frederick Pei Li）与约瑟夫·芬曼恩二世博士（Dr. Joseph Fraumeni Jr.）首次相遇，尚未知道他们将帮助做出开创性发现，这一发现将在癌症患者中影响数十年——到今天，英格里西亚和其他无数人继续解开并构建利和芬曼恩最初的发现，并理解这对他们的家庭意味着什么。

在看似难以承受的失去面前，英格里西亚保持着希望。他敦促我们要“像查理一样战斗”，他的侄子，一生都在与癌症斗争，从两岁时脸上的罕见肿瘤开始——并且要看向未来，基因测序、筛查程序、CRISPR基因编辑以及其他正在发展的技术或许将继续延长寿命，并可能有一天甚至提供治愈。

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