癌症研究中的核磁共振代谢组学（NMR metabolomics）

English | ASIN: B00HMQCUT4 | 446 pages | PDF | 2012 | 27 Mb

The application of nuclear magnetic resonance (NMR) metabolomics in cancer research requires an understanding of the many possibilities that NMR metabolomics can offer, as well as of the specific characteristics of the cancer metabolic phenotype and the open questions in cancer research. NMR metabolomics in cancer research presents a detailed account of the NMR spectroscopy methods applied to metabolomics mixture analysis along with a discussion of their advantages and disadvantages. Following an overview of the potential use of NMR metabolomics in cancer research, the book begins with an examination of the cancer metabolic phenotype and experimental methodology, before moving on to cover data pre-processing and data analysis. Chapters in the latter part of the book look at dynamic metabolic profiling, biomarker discovery, and the application of NMR metabolomics for different types of cancer, before a concluding chapter discusses future perspectives in the field. Focused description of NMR spectroscopy needed by cancer biologists who are starting to use metabolomics Current overview of knowledge related to the cancer metabolic phenotype from the perspective of metabolomics applications

核磁共振（NMR）代谢组学在癌症研究中的应用需要了解NMR代谢组学所能提供的多种可能性，以及癌症代谢表型的具体特征和癌症研究中尚未解决的问题。关于癌症研究的NMR代谢组学一书详细介绍了用于代谢组学混合分析的NMR光谱方法，并讨论了它们的优点和缺点。该书首先概述了NMR代谢组学在癌症研究中的潜在用途，然后从癌症代谢表型及其实验方法入手，接着涵盖了数据预处理和数据分析。书的后半部分探讨了动态代谢图谱 profiling、生物标志物发现以及如何将NMR代谢组学应用于不同类型的癌症，最后在一章中讨论了该领域的未来前景。 对开始使用代谢组学的癌症生物学家来说，需要详细描述用于癌症研究的NMR光谱方法。 从代谢组学应用的角度来看，当前对癌症代谢表型的知识概述。

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