癌症中的药物耐药性：机制与策略 - Sameer Ullah Khan

English | May 7, 2024 | ISBN-10: 9819716659 | 401 pages| Epub PDF (True) | 43 MB

This book tries to emphasize the mechanisms associated with the resistance towards various anti-cancer therapies The focus has been given to the role of cancer stem cells, immune cells, and the multiway impact of tumor microenvironment in drug resistance. The book delves into the role of epigenetic alterations, autophagy, intracellular compartments, and the impact of gut microbiome on therapeutic resistance. Each chapter of the book has elaborated on these aspects that are exclusively or mutually driving the therapeutic non-responsiveness towards various current clinical candidates. In addition to that the book has also discussed novel strategies to overcome the therapeutic challenge by employing combinatorial therapies that can prove to be useful and effective. Overall the book reflects on the current treatment challenges, futuristic strategies and new research initiatives that explore novel treatment options.

这本书试图强调与各种抗癌疗法抗性相关的机制，重点在于癌干细胞、免疫细胞和肿瘤微环境的多方面影响在药物抗性中的作用。本书深入探讨了表观遗传变化、自噬、内脏器官以及肠道微生物组对治疗抗性的影响。每一章节都详细阐述了这些因素，在这些因素分别或共同驱动各种当前临床候选物的治疗无效。此外，这本书还讨论了通过采用组合疗法来克服治疗挑战的新策略，这些新策略既是有用又有效的。总的来说，这本书反映了目前的治疗挑战、未来的战略和新的研究举措，探索新的治疗方法。

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