《雷诺病：从发病机制到管理》第二版

English | 2024 | ISBN-10: 3031525809 | 460 pages| PDF (True) | 23 MB

This book comprehensively reviews the understanding of a disorder that continues to challenge primary care clinicians and specialists. Raynaud’s phenomenon is an inappropriate and exaggerated response of the digital and cutaneous circulation to cold environmental temperatures. It is common, often causing significant morbidity and it is a major challenge for physicians at every level and specialty. A comprehensive review of Raynaud’s is now timely because of the incredible progress in understanding the molecular mechanisms of the normal regulation of cutaneous blood flow and how disease can disrupt the function of these specialized vessels. Likewise, the clinical implications of Raynaud’s phenomenon are better appreciated with studies defining its prevalence, the associated diseases, and new treatment approaches for patients suffering from it. The nomenclature used to classify cases has changed over the years and is important to understand these terms both for clinical care andresearch. This fully updated second edition comprehensively discusses various causes of Raynaud’s phenomenon including childhood Raynaud’s phenomenon, Raynaud’s phenomenon secondary to connective tissue disease, occupational causes, and a variety of other associated disorders. Careful consideration is given to the diagnosis of Raynaud’s phenomenon with state of the art discussion of nailfold capillary examination, non-invasive imaging, angiography, and appropriate serological testing. The concept that Raynaud’s phenomenon is associated with systemic disease or can be the manifestation of a systemic vasospastic disorder is also presented. In addition to reviewing both non-drug and drug therapy for patients with Raynaud’s phenomenon, this volume provides a practical approach in specific clinical situations by presenting problematic cases and the authors’ expert opinions on therapy. It also discusses mechanisms contributing to the vascular dysfunctionof primary Raynaud’s phenomenon and the vascular disease of secondary Raynaud’s phenomenon.

这本书全面回顾了继续挑战初级护理医生和专家的理解的一种持续性障碍。雷诺现象是对寒冷环境温度的数字和皮肤循环的不适当和过度反应。它很常见，经常导致显著的疾病负担，并且是每个层次和专科医生面临的主要挑战。由于对正常调节皮肤血流的分子机制以及疾病如何干扰这些特化的血管功能的理解取得了巨大进展，现在关于雷诺现象的全面回顾已经到了恰当的时机。同样地，雷诺现象患者的临床意义也随着研究定义其患病率、相关疾病及其治疗的新方法而得到了更好的理解。 随着时间推移，“雷诺现象”的分类术语已发生变化，对于临床护理和研究都非常重要。 此次完全更新的第二版综合讨论了多种类型的雷诺现象病因，包括儿童型雷诺现象、由结缔组织疾病引发的雷诺现象、职业因素引发的雷诺现象以及一系列其他相关病症。仔细考虑对雷诺现象的诊断，并进行了现代讨论，即指甲皱褶毛细血管检查、非侵入性成像、血管造影和适当的血清学检测。还介绍了雷诺现象与系统性疾病有关的概念，或者可以作为系统性血管痉挛障碍的表现。 除了讨论患者患有雷诺现象时的药物治疗和非药物治疗方法外，本卷通过提出有争议病例及其作者在治疗方面的专家意见来提供具体临床情况下的实用方法。此外，本书还探讨了主要雷诺现象的血管功能障碍机制以及继发性雷诺现象的血管疾病机制。

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