离子通道作为药物发现的目标

English | 2024 | ISBN: 303152196X | 546 Pages | PDF EPUB (True) | 47 MB

This book is built around ion channel research and, more specifically, ion channels as important therapeutic drug targets. Under the editorial leadership of Gary Stephens in academic research and Edward Stevens from industry, the aim is to bring these strands together to provide a cutting-edge translational reference on ion channel drug discovery. Exploiting our knowledge of ion channel structure and function has clear current and future potential to intervene and correct the pathophysiology associated with debilitating conditions, including cardiovascular disease, diabetes, cystic fibrosis, pain, epilepsy, and neurodegenerative disorders. Individual chapters have a disease focus, also providing a “case study story” that will also appeal to a clinical audience, while background information on a given ion channel is presented to provide a solid reference for undergraduate and postgraduate teaching.

这本书围绕离子通道研究构建，并且更具体地说，是离子通道作为重要的治疗药物靶点的研究。在学术研究的编辑领导Gary Stephens和工业界的Edward Stevens的领导下，目的是将这些线索结合起来，提供一本尖端转化参考书，内容关于离子通道药物发现。利用我们对离子通道结构和功能的知识，已经具有当前和未来的潜力来干预并纠正导致诸如心血管疾病、糖尿病、囊性纤维化、疼痛、癫痫和神经退行性疾病等使人衰弱的条件的病理生理学。每个章节都有一个疾病焦点，同时也为临床观众提供了一个“案例研究故事”，此外还提供了给定离子通道的背景信息，以供本科生和研究生教学使用作为坚实参考。

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