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临床实践中癌症遗传学指导手册

English | ISBN: 1903378540 | 2009 | 246 pages | EPUB | 3 MB

FIRST PRIZE Winner in the Oncology category of the 2010 BMA Medical Book Competition. Intensive research over the last fifteen years has yielded a vast expansion in our understanding of the role of inheritance and genetics in a variety of cancers. Several inherited conditions have been identified which result in a high risk of various cancers; some of these were previously recognized, but the genetic basis underlying them has now been elucidated. This knowledge is now entering the sphere of routine clinical care. Surgeons, gastroenterologists, gynaecologists, oncologists, endocrinologists and many others need an awareness of these disorders, an understanding of genetic testing and when it is indicated, and how to manage patients with inherited cancer predisposition and their families. This book covers the basic concepts of cancer genetics. The common inherited cancer syndromes are each dealt with in greater depth, with the current management outlined. This book is aimed at all clinicians who may encounter these conditions in their practice. It aims to facilitate identification of high-risk individuals and families, to inform interaction with geneticists and other subspecialists, to provide a basis for patient management and to stimulate interest in these fascinating conditions.


2010年BMA医学图书竞赛 Oncology类别一等奖。过去十五年来的深入研究,使我们对遗传和基因在各种癌症中的作用有了很大的扩展理解。已发现了几种由高风险多种癌症引起的遗传条件;其中有些之前已经被认识到,但现在已经阐明了它们的遗传基础。这些知识现在正在进入常规临床护理领域。外科医生、胃肠科医生、妇科医生、肿瘤学家、内分泌科医生以及其他许多人都需要了解这些紊乱的知识,理解遗传检测以及何时进行,以及如何管理有遗传癌症易感性的人及其家庭。这本书涵盖了癌症遗传的基本概念。常见的遗传性癌症综合征被更深入地处理,并概述了当前的管理方法。这本书的目标是所有可能在实践中遇到这些条件的临床医生。它的目的是识别高风险个体和家庭,提供与遗传学家和其他亚专科医生互动的信息,为患者的管理和激发对这些有趣条件的兴趣。
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