脑对肾上腺激素的作用

English | PDF | 1982 | 156 Pages | ISBN : 364268338X | 27.5 MB

In 1968 we reported that the hippocampus of adrenalectomized rats takes up and retains 3H-corticosterone (McEwen et al. 1968). This and subsequent studies, which were intended to identify and localize sites of adrenal steroid feedback in the central nervous system in terms of putative receptor mechanisms, were stimuli for a variety of investigations into the role of the hippocampus in adrenal steroid feedback on ACTH secretion and on behavior. In this respect, the identification of putative receptor sites was the impetus for the search for the function of glucocorticoids in hippocampus and in the rest of the brain. That search now seems to be coming to fruition. This article is a summary of the highlights of the search and the new information and perspectives which are corning out of it.

1968年，我们报道过切除肾上腺的鼠的海马区能够摄取并保留3H-皮质醇（McEwen等，1968）。这些后续的研究，旨在通过假定受体机制来识别和定位大脑中枢神经系统中的肾上腺类固醇反馈部位，成为了关于海马在ACTH分泌以及行为中对肾上腺类固醇反馈作用的各种研究的刺激。在此方面，假定受体位点的识别是寻找皮质激素在海马以及脑部其他区域功能的动力。这项搜索似乎即将取得成果。本文是对这一搜索的要点总结，同时还包括了新信息和观点。

---

Download from free file storage

 Download from nitroflare.com  Download from upfiles.com  Download from rapidgator.net

---

我要反馈

---

本站不对文件进行储存，仅提供文件链接，请自行下载，本站不对文件内容负责，请自行判断文件是否安全，如发现文件有侵权行为，请联系管理员删除。