《美丽之死：肉毒杆菌的历史变革》[有声书]

English | ASIN: B0CZYJV6GS | 2024 | MP3@64 kbps | ~06:38:00 | 182 MB

Eugene M. Helveston, Kyle Snyder (Narrator), "Death to Beauty: The Transformative History of Botox"

In the 1970s, Dr. Alan Scott sought to selectively weaken eye muscles to treat strabismus (when one or both eyes are misaligned) without surgery. After failed attempts with other agents, Scott developed a method to stabilize the bacteria that causes botulism, culminating in a drug that eventually became known as Botox.

In Death to Beauty, Eugene M. Helveston, MD, follows the unlikely story of botulism's 1817 discovery in contaminated German sausages, to its use in military and research facilities, to Scott, an ophthalmologist who aimed to safely use the drug in humans. Scott struggled alone as an unknown in the pharmaceutical industry, searching for clinical trial financing and FDA approval, which he achieved at a fraction of the billions big pharma usually spends to bring a drug to market. Eventually, the company Allergan bought him out, capitalizing on the possibilities for cosmetic uses. Scott's formula was renamed "Botox" and reached annual sales in the billions. After the sale, Scott received no further compensation from Botox sales and remained the same unassuming man.

A fascinating walk through the intricate history of how the world's deadliest toxin starting as a treatment for crossed eyes became a routine tool for the cosmetic industry, Death to Beauty will make you rethink success, beauty, and deadly bacteria.

Eugene M. Helveston, Kyle Snyder (Narrator), "死亡之美：肉毒杆菌的 transformative 历史"

在 20 世纪 70 年代，Alan Scott 教授试图通过减弱眼肌来治疗斜视（当一只或两只眼睛不正时），而不进行手术。经过其他药物尝试失败后，Scott 推出了稳定肉毒杆菌的方法，最终发展成了一种后来被称为肉毒杆菌素的药物。

在《死亡之美》中，Eugene M. Helveston, MD 遥不可及地讲述了肉毒杆菌在 1817 年被不知名的人发现于受污染的德国香肠中的故事，再到它在军事和研究设施中的使用，直到 Scott 教授作为一名眼科医生试图安全地将药物用于人类。Scott 单独艰难地在制药行业寻找临床试验资金和 FDA 批准，在成本仅是大药厂通常花费以使药物进入市场的一小部分的情况下实现了这一点。最终，Allergan 公司买下了他，利用了化妆品用途的可能性。 Scott 的配方被改名为“肉毒杆菌素”，销售额达到了每年数十亿美元。在交易之后，Scott 没有因肉毒杆菌素销售收到进一步的补偿，并且仍然是那个谦逊的人。

这本《死亡之美》提供了一个关于如何世界最致命毒素从治疗斜视开始的历史详尽介绍，它最终成为美容业常规工具的世界之旅。这将让你重新思考成功、美丽和致命细菌。

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