辣椒素：从天然来源到生物合成及其临床应用

English | 2024 | ISBN-10: 9819977789 | 585 pages| PDF (True) | 13 MB

This edited book brings out a comprehensive collection of information on capsaicinoids. Primarily, this book includes compiled knowledge on various aspects of capsaicin from ethnobotany to the most important clinical applications. This book covers topics emphasizing chemistry, biosynthesis, anticancer activities, bioavailability, currently undergoing experimental phases, and biotechnological methods, including cell cultures, and metabolic engineering in heterologous microbial and plant systems to enhance capsaicin production. Capsaicinoids are a group of important compounds that are particularly synthesized by various members of the genus Capsicum in their placenta. Capsaicin is the most abundant vanilloid compound among the different capsaicinoids in hot peppers. Other capsaicinoids include dihydrocapsaicin, nordihydrocapsaicin, homocapsaicin, and homodihydrocapsaicin. The capsaicin has been proven as an important bioactive molecule with several properties against many ailments, such as cancer, diabetes, obesity and diseases of the airway and urinary tract. Capsaicin interacts with TRPV1 receptors in humans. These compounds exert their functions by interacting with the TRPV receptors. This book summarises the increasing literature surrounding capsaicin and helps to pave the way for the development of novel targets for the prevention and treatment of many disorders. It is useful for scientists, clinicians, and industry specialists working in the field of herbal therapeutics. It also assists as supplementary reading material for undergraduate and graduate students of botany, biotechnology, biochemistry, bioengineering, pharmacology, and medicine.

这本书全面汇集了辣椒素的信息。首先，本书涵盖了从药用植物学到临床应用最为重要的各种辣椒素的知识。本书强调了化学、生物合成、抗癌活性、生物利用度以及目前处于实验阶段的各种方法，并包括细胞培养和异源微生物及植物系统的代谢工程等技术来增强辣椒素的生产。辣椒素是一组重要的化合物，它们由辣椒属的不同成员在果实中产生。辣椒素是热辣椒中含量最多的辣椒素类化合物。其他辣椒素还包括二氢辣椒素、反式-二氢辣椒素、去甲基化辣椒素和去甲基化二氢辣椒素。已证明辣椒素是一种对抗许多疾病的生物活性分子，例如癌症、糖尿病、肥胖症以及呼吸道疾病和泌尿系统疾病。这些化合物通过与TRPV1受体相互作用发挥其功能。 本书总结了关于辣椒素文献的日益增长的信息，并为预防和治疗多种病症提供了新的靶标的发展道路。对于从事草药疗法研究的科学家、临床医生和行业专家有帮助。它也作为植物学、生物技术、生物化学、生物工程、药理学和医学本科生和研究生补充阅读材料的作用。

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