哈珀儿科皮肤病学，第一卷，第4版

English | 2020 | ISBN: 1119142199 | True (PDF/EPUB) | 2535 pages | 425 MB/232 MB

Children´s skin is different. Maturation affects the epidermal barrier, the cutaneous microbiome, adnexal structures, vasculature, and transcutaneous absorption of drugs. The immature skin is more susceptible to pathogens and environmental disruption. Many genetic disorders are either present at birth or manifest early in childhood. Skin diseases thus present differently in children than in adults. Pediatric dermatology has seen significant advances over the last decade, particularly in the field of molecular genetics research, which has furthered our understanding of the pathogenesis of many skin diseases and the development of new approaches to treatment.

儿童的皮肤不同。成熟过程影响角质层屏障、皮脂微生物群、附属结构、血管以及药物经皮吸收。未成熟的皮肤更易受病原体和环境破坏的影响。许多遗传性疾病要么在出生时就存在，要么在儿童早期显现出来。因此，皮肤病在儿童中的表现与成人不同。过去十年中，儿科皮肤病学取得了显著进步，特别是在分子遗传学研究领域，在该领域的推动下，我们对许多皮肤疾病的发病机制有了更深入的理解，并开发了新的治疗方法。

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