ESKAPE病原体：检测、机制和治疗策略

English | 2024 | ISBN: 9819987989 | 556 Pages | PDF EPUB (True) | 33 MB

This book explores the medical importance of Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp. (ESKAPE) pathogens, and the challenges posed by antibiotic resistance. It covers the antibiotic resistance profile and detection of ESKAPE pathogens, as well as the mechanistic understanding of antibiotic resistance in these pathogens. The book discusses standard microbiological techniques, including staining, morphological and cultural characteristics, biochemical properties, and serotyping, as well as nucleic acid amplification and molecular diagnostic techniques for the detection of ESKAPE pathogens. In addition, the book explores biochemical, molecular, and computational techniques for the determination of virulence factors of ESKAPE pathogens. It also examines the synthesis, structure, function, and inhibitors of virulence factors and biofilm componentsin these pathogens. The book explores various strategies for combating ESKAPE pathogens, including antibiotic adjuvants and their synergistic activity, phytochemicals as potential antibacterial agents, photodynamic therapy, antimicrobial peptides and antibacterial antibodies, antimicrobial activity of Nanomaterials and Nanocomposites, and bacteriophage therapy. Finally, the book discusses in silico and computational approaches for the inhibition of ESKAPE pathogens. This comprehensive book is of interest to researchers, students, and healthcare professionals interested in the diagnosis, prevention, and treatment of ESKAPE pathogens.

这本书探讨了Enterococcus faecium、Staphylococcus aureus、Klebsiella pneumoniae、Acinetobacter baumannii、Pseudomonas aeruginosa 和 Enterobacter spp. (ESKAPE) 病原体的医学重要性，以及抗菌耐药性带来的挑战。它涵盖了 ESKAPE 病原体的抗菌耐药性谱型和检测方法，还探讨了这些病原体中的抗菌耐药性的机制理解。本书讨论了标准微生物技术，包括染色、形态学和培养特性、生化属性以及血清分型，以及用于检测 ESKAPE 病原体的核酸扩增和分子诊断技术。此外，该书还探索了 ESKAPE 病原体致病因子化学鉴定、分子识别以及计算分析的技术方法。它还研究了这些病原体中耐药性因子和生物膜组分的合成、结构、功能及抑制剂。本书探讨了针对 ESKAPE 病原体的各种策略，包括抗生素辅助剂及其协同活性、植物化学物作为潜在抗菌剂、光动力疗法、抗菌肽和抗菌抗体，以及纳米材料和纳米复合物的抗菌活性，以及噬菌体治疗。最后，该书讨论了用于抑制 ESKAPE 病原体的计算及分子方法。这本书对那些对诊断、预防和治疗ESKAPE病原体感兴趣的科研人员、学生和医疗专业人士具有浓厚的兴趣。

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