器官移植中的气体传递者

English | 2024 | ISBN: 303148066X | 317 Pages | PDF EPUB (True) | 10 MB

This book covers recent pre-clinical and clinical developments in gasotransmitters (nitric oxide, carbon monoxide and hydrogen sulfide) in all transplantable solid organs – kidney, heart, lung, liver, pancreas and intestine. Gasotransmitters are a class of small endogenously produced gaseous signaling molecules that play important roles in cellular homeostasis and impact physiological and pathophysiological situations. Recently, these gasotransmitters have emerged as potent cytoprotective mediators, possessing therapeutic properties that enable them exhibit their intracellular signaling functions. Hence, alterations in their physiological levels have been associated with various pathologies including cold ischemia-reperfusion injury (IRI) in organ transplantation.

这本书涵盖了固有器官移植（肾脏、心脏、肺、肝脏、胰腺和肠道）中的气体信使（一氧化氮、二氧化碳和硫化氢）的近期前临床和临床发展。气体信使是一类小的内生产生的气体信号分子，它们在细胞稳态中发挥着重要作用，并影响生理和病理生理情况。最近，这些气体信使被发现是强有力的细胞保护中介者，它们具备治疗特性，能够表现出其胞内的信号传递功能。因此，它们的生理水平的变化与器官移植中的多种疾病包括冷缺血再灌注损伤（IRI）有关。

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