Monika Schäfer-Korting的药物递送和靶向技术

English | 2024 | ISBN: 3031528638 | 421 Pages | PDF EPUB (True) | 54 MB

Since the publication of the Handbook of Experimental Pharmacology Vol. 197 in 2010 there have been important advances in drug development, drug delivery and – more recently – drug targeting. This is in particular relevant with the new generation of drugs acting on the immune system and tumors. These are quite often accompanied by major adverse reactions. Safe therapy is, therefore, an important area of research, in particular in chronic diseases and in persons of old age. In addition, the Covid-19 pandemic has brought renewed attention to vaccinations against viral infections, and mRNA vaccines have been tested for vaccination in tumor therapy, too. Vaccine delivery has stimulated important research on carriers which may pave the way for other applications and enhance a path to e.g. CRISPR-cas therapy.

自2010年《实验药理学手册》卷197出版以来，药物开发、药物递送方面取得了重要进展，而最近又在药物靶向领域取得进步。特别是在针对免疫系统和肿瘤的新一代药物方面尤其相关。这些药物经常伴有严重的副作用反应。因此，安全治疗成为了一个重要的研究领域，尤其是在慢性疾病和老年人群中更为重要。此外，新冠肺炎疫情的爆发再次引起了对预防病毒感染疫苗的关注，mRNA疫苗也已用于肿瘤治疗的测试。疫苗递送的研究刺激了有关载体的重要研究，这可能为其他应用铺平道路，并有助于如CRISPR-cas疗法的发展之路。

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