卵巢癌：从诊断到减瘤手术和化疗的“妇科挑战”。卷1 & 2

VOLUME 1 Ovarian cancer is one of the deadliest gynaecological cancers. In most cases, it is detected as an advanced tumor, since early diagnosis is challenging for most forms of the disease. Surgery and platinum-based compounds have been the mainstay of therapy for many years. The prognosis for ovarian cancer depends on the type of surgery and on the response to chemotherapy. Other regimens have little effect if the disease does not respond to platinum. However, several new therapies are emerging including bevacizumab and PARP-inhibitors, among others. This book provides a detailed body of information important to an understanding of the clinical aspects and management of such a challenging disease. The authors strive to provide the physician with insights and illustrations as well as useful tips and tricks for the everyday clinical practice. Several world-known experts in the field participated in this fruitful effort offering their knowledge and everyday experience, as well as valuable and original photos from their personal archives as well as the most recent and up-to-date guidelines in the field.

In this book, we evaluate all the challenging pathways from the moment of diagnosis to the surgical and medical therapies. The pathogenesis, the variation of the morphological types and the problems in differential diagnosis are also discussed. Moreover, we provide an overview of recent attempts to improve the diagnosis and prognosis of ovarian cancer as well as a discussion of fertility sparing alternatives and minimal invasive (laparoscopic and robotic) approaches. All the new diagnostic and therapeutic strategies that lay out the foundation for these improvements are presented. Areas of future research are also discussed, supported by a wealth of up-to-date reference material. The book is written at a level appropriate for both medical students, physicians as well as gynaecological oncologists, pathologists, and medical oncologists. VOLUME 2 Ovarian cancer is one of the deadliest gynaecological cancers. In most cases, it is detected as an advanced tumor, since early diagnosis is challenging for most forms of the disease. Surgery and platinum-based compounds have been the mainstay of therapy for many years. The prognosis for ovarian cancer depends on the type of surgery and on the response to chemotherapy. Other regimens have little effect if the disease does not respond to platinum. However, several new therapies are emerging including bevacizumab and PARP-inhibitors, among others. This book provides a detailed body of information important to an understanding of the clinical aspects and management of such a challenging disease. The authors strive to provide the physician with insights and illustrations as well as useful tips and tricks for the everyday clinical practice. Several world-known experts in the field participated in this fruitful effort offering their knowledge and everyday experience, as well as valuable and original photos from their personal archives as well as the most recent and up-to-date guidelines in the field.

第一卷 卵巢癌是妇科恶性肿瘤中死亡率最高的疾病之一。大多数情况下，它是作为晚期肿瘤被发现的，因为对这种疾病的早期诊断对于大多数人来说都是具有挑战性的。手术和铂类化合物一直是多年来治疗的主要手段。卵巢癌的预后取决于手术类型以及化疗反应的程度。如果疾病不响应铂类药物，其他方案的效果就不太明显。然而，几种新的疗法正在涌现，包括贝伐单抗和PARP抑制剂等。这本书提供了理解这种极具挑战性疾病的临床方面和管理所必需的重要信息的详尽资料。作者努力向医生提供见解、插图以及日常临床实践中有用的建议和技巧。

在本书中，我们评估从诊断到手术及医疗疗法的所有具有挑战性的途径。病生理机制、形态类型的变化以及鉴别诊断中的问题也进行了讨论。此外，我们概述了最近的努力来改善卵巢癌的诊断和预后，并探讨了保留生育能力的选择以及微创（腹腔镜和机器人）方法。所有这些新诊断和治疗策略都呈现在这里，它们构成了这些改进的基础。还讨论了未来的研究领域，并由最新的参考资料支持。

本书适合医疗学生、医生以及妇科肿瘤学家、病理学家及内科肿瘤学家阅读。

第二卷 卵巢癌是妇科恶性肿瘤中死亡率最高的疾病之一。大多数情况下，它是作为晚期肿瘤被发现的，因为对这种疾病的早期诊断对于大多数人来说都是具有挑战性的。手术和铂类化合物一直是多年来治疗的主要手段。卵巢癌的预后取决于手术类型以及化疗反应的程度。如果疾病不响应铂类药物，其他方案的效果就不太明显。然而，几种新的疗法正在涌现，包括贝伐单抗和PARP抑制剂等。这本书提供了理解这种极具挑战性疾病的临床方面和管理所必需的重要信息。作者努力向医生提供见解、插图以及日常临床实践中有用的建议和技巧。几位在该领域享有盛誉的专家参与了这项富有成果的努力，分享了他们的知识和日常经验，以及他们个人档案中珍贵且原创的照片，并提供了最新的指南。

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