线粒体的动态性质：从超结构到健康与疾病

English | 2024 | ISBN: 9781003221180 | 211 pages | True PDF | 12.72 MB

Mitochondrial research has exploded over the last ~150 years. This book gives an amazing view on a conceptual change in our understanding of mitochondrial biology. It becomes clear that mitochondria are extremely dynamic in nature, controlling life at multiple levels. Mitochondria rule energy conversion, adapt cells well to changing stress and nutrient conditions, and regulate many cellular processes including immunity. The dynamic nature of mitochondria occurs at an intramitochondrial level but also includes its ability to interact with other organelles and to modulate multiple signalling pathways. It is thus not surprising that alterations or inabilities to ensure this dynamic behaviour is linked to ageing and human diseases.

The following sections give an updated view on mitochondria

Mitochondrial ultrastructure: molecular mechanisms shaping the inner membrane Mitochondrial cristae and lipid dynamics: from super-resolution microscopy to lipid-OXPHOS interplay Mitochondrial control of cellular homeostasis: from redox signalling to interorganellar contact sites Mitochondria in health and disease: from mtDNA release to Complex I assembly Advanced methods in mitochondrial biology and metabolism research Integrative view on mitochondrial research and outlook The field of mitochondrial research has always been full of surprises and has helped science to advance tremendously. It developed hand in hand with landmark developments in technology, such as super-resolution microscopy (nanoscopy), and is currently influencing an increasing number of scientific disciplines. There is still much ‘new’ to find out about this ‘old’ organelle and I think that you can find interesting and also unexpected aspects of mitochondrial biology in this book. I hope the book will enhance your scientific curiosity and inspire your own research.

线粒体研究在过去大约150年里急剧增加。这本书提供了一个关于我们对线粒体生物学理解概念性转变的惊人视角。清楚地表明，线粒体在多个层次上控制着生命活动。线粒体会调控能量转换，很好地适应细胞所遇到的各种压力和营养条件，并调节许多细胞过程，包括免疫系统。线粒体的动态特性体现在其内部水平上，同时也包括它与其它器官体的相互作用以及调节多种信号通路的能力。因此，对这种动态行为的改变或无法维持的现象与衰老及人类疾病之间存在关联是不足为奇的。 接下来的部分提供了线粒体的更新观点 线粒体超微结构：塑造内膜的分子机制 线粒体内嵴和脂质动态：从超级分辨率显微镜到脂氧素-三羧酸循环相互作用 线粒体对细胞稳态的控制：从氧化还原信号传导到器官间接触位点 健康与疾病中的线粒体：从mtDNA释放到复合物I组装 线粒体生物学和代谢研究中高级方法 线粒体研究的整体视角及展望 线粒体研究领域始终充满了惊喜，并且极大地推动了科学的进步。它与技术领域的重大进展（例如超级分辨率显微镜纳米显微术）相伴而生，现在正在影响越来越多的科学研究领域。对于这个“古老”的器官来说，仍有许多“新”东西需要发现。我认为这本书中可能有有趣的以及意想不到的线粒体生物学方面。我希望这本书能够增强你的科学好奇心，并激发你自己的研究灵感。

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