脊椎动物骨骼和牙齿组织矿化的机制

English | PDF EPUB (True) | 2024 | 513 Pages | ISBN : 3031343026 | 153 MB

The book presents a multi-disciplinary approach to understanding mechanisms regulating the formation of mineral in vertebrate skeletal and dental tissues. The focus of the book is directed toward the mineralization process, an evolutionarily conserved system in which cells synthesize a complex and unique extracellular matrix into which mineral is deposited. Regulatory control is viewed though lenses that emphasize the genetic, physical-chemical, biochemical, structural, cellular and extracellular aspects of the mineralization process as they relate to crystal nucleation, growth and maturation. Throughout the book, defects in regulation at the genetic and transcriptional levels are linked to the numerous clinical problems associated with the mineralization of bone, cartilage, tendon, tooth, and soft tissues. The book serves as a comprehensive text for basic scientists and scholars working in the many areas that comprise hard tissue research, as well as undergraduate and graduate students, postdoctoral fellows and those contemplating working in the field of biomineralization or who need a review of a specific mineralization topic. The information contained in the book is relevant for clinicians and clinical scientists in the fields of orthopaedic surgery, veterinary medicine, dentistry, endocrinology, aging and genetics.

这本书以多学科方法来理解脊椎动物骨骼和牙齿组织中矿物质形成机制。本书的重点在于矿物化过程，这是一个在进化上保守的系统，在此过程中细胞合成了一种复杂的、独特的胞外基质，在其中沉积了矿物质。通过强调与晶体成核、生长和成熟相关的遗传学、物理化学、生化、结构、细胞和细胞外方面来看待调控控制。全书始终将基因和转录水平上的调节缺陷与其在骨、软骨、腱、牙齿及软组织中的矿物化临床问题联系起来。 本书适用于基本科学家和从事众多组成硬组织研究领域的学者，也适用于本科和研究生学生、博士后研究员以及考虑在生物矿化领域工作的人员或需要了解特定矿物化主题的回顾。书中包含的信息对骨科手术、兽医医学、牙科、内分泌学、老化及遗传学领域的临床医生和临床科学家来说也很相关。

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