面对黑热病的挑战与解决方案

English | 2024 | ISBN-10: 9819969980 | 470 pages| Epub PDF (True) | 31 MB

This book comprehensively reviews the epidemiology and surveillance strategies of Visceral Leishmaniasis, and the latest developments in disease diagnosis, drug discovery, and vaccine development. The initial chapters cover the epidemiology features and spatial distribution of Visceral Leishmaniasis. The book further discusses the manifestations of HIV-Visceral Leishmaniasis infection on the immunopathogenesis, diagnosis, and therapeutic response. It analyzes the role of different proteomic technologies in understanding the parasite development, survival, drug resistance mechanisms, host-pathogen interactions, and the development of new therapeutic approaches. The book concludes by discussing recent advancements in vaccine development for Visceral Leishmaniasis. It discusses the promising vaccine candidate, their developmental status, current challenges, and prospects for rational vaccine development against Leishmania. This book is an invaluable source of information for students, and researchers working to understand the Leishmania biology, and drug development.

这本书全面回顾了非洲锥虫病的流行病学和监测策略，并介绍了疾病诊断、药物发现以及疫苗研发的最新进展。前几章涵盖了非洲锥虫病的流行病学特征及其空间分布。该书进一步探讨了艾滋病与非洲锥虫病感染对免疫病理学的影响、诊断方法及治疗反应。它分析了不同蛋白质组技术在理解寄生虫发育、生存机制、耐药性机制、宿主-病原体相互作用方面的作用，以及开发新治疗方法的重要性。最后讨论了针对非洲锥虫病的疫苗研发的最新进展。讨论了具有前景的候选疫苗及其发展状态、当前面临的挑战以及开发合理疫苗的前景。该书对理解利什曼原虫生物学和药物开发的学生和研究人员来说是一份宝贵的资料来源。

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