放射治疗学：对医用物理学家的简介 I 物理、化学、生物学和临床应用

English | 2024 | ISBN: 9781003250913 | 231 pages | True PDF | 22.64 MB

This book covers scientific, clinical, and educational aspects of radiotheranostics in cancer control. Setting the framework, the first volume defines radiotheranostics and describes the history of radionuclide therapy and theranostics, and the biology of cancer. It examines the clinical applications of unconjugated radionuclides, such as ¹³¹I and ²²³Ra, and of radionuclide-conjugated cancer-specific vectors: peptides, small molecules, antibodies, and nanoparticles; introduces clinical trials and drug development; and reviews epidemiological studies and the adverse effects of radionuclide therapy – both radiation injuries and chemical toxicity. It presents the chemistry and physics of radionuclide production, discusses radioactivity measurements and traceability, and addresses important instrumentation aspects: calibration, quantitative imaging, and quality control. Volume I concludes with guidance on the education, training, and competence of a radiotheranostic multidisciplinary team and summarizes the principal physics characteristics of theranostics today – including many to be expanded in the second volume – while offering a glimpse into tomorrow. This volume provides the foundations for the more advanced second volume, which explores dosimetric and radiation safety, aiming to empower medical physicists and demonstrate to the cancer community how to improve cancer control and yield increased patient survival times.It will be a valuable reference for medical and health physicists with basic knowledge of nuclear medicine.

Key Features • Provides a comprehensive introduction to the topic, presenting readers with thorough treatment in a cohesive two-volume book. • Presents a rigorous approach while remaining accessible to students and trainees in the field. • Contains consistent and extensive references to allow readers to delve deeper into the subject.

这本书涵盖了癌症控制中放射治疗学的科学、临床和教育方面的内容。首先，第一卷定义了放射治疗学，并描述了放射性核素疗法和放射治疗的发展历史以及癌生物学。它研究了未结合放射性核素的应用，如¹³¹I 和²²³Ra，放射性核素标记癌症特异性载体：肽、小分子、抗体和纳米粒子；介绍了临床试验和药物开发；并回顾了放射性核素疗法的流行病学研究以及放射性核素疗法带来的不良反应——既包括辐射损伤也包括化学毒性。它呈现放射性核素生产的化学和物理特性，讨论放射性测量与溯源，并涉及重要仪器方面：校准、定量成像和质量控制。第一卷以指导放射治疗多学科团队的教育、培训和能力结束，并总结了目前放射治疗学的主要物理特征——包括将在第二卷中扩展的内容——并为读者提供一个关于明天的概览。此卷提供了用于探索第二卷中更高级内容的基础，该卷将探讨剂量率及辐射安全问题，以支持放射物理学家并向癌症社区展示如何改善癌症控制并提高患者的生存时间。对于具有基本核医学知识的医疗和健康物理学家来说，这是一个有价值的参考书。 关键特点 • 提供一个全面的介绍，通过一本有机编写的两卷书籍来为读者提供完整的治疗。 • 保持对领域中学生和训练者的可访问性的同时采取严格的方法。 • 包含一致且详尽的引用，以帮助读者深入研究主题。

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