癌症免疫疗法：免疫抑制与肿瘤生长

English | June 18, 2007 | ISBN-10: 0123725518 | 428 pages| Epub PDF (True) | 11.3 MB

There has been major growth in understanding immune suppression mechanisms and its relationship to cancer progression and therapy. This book highlights emerging new principles of immune suppression that drive cancer and it offers radically new ideas about how therapy can be improved by attacking these principles. Following work that firmly establishes immune escape as an essential trait of cancer, recent studies have now defined specific mechanisms of tumoral immune suppression. It also demonstrates how attacking tumors with molecular targeted therapeutics or traditional chemotherapeutic drugs can produce potent anti-tumor effects in preclinical models. This book provides basic, translational, and clinical cancer researchers an indispensable overview of immune escape as a critical trait in cancer and how applying specific combinations of immunotherapy and chemotherapy to attack this trait may radically improve the treatment of advanced disease.* Offers a synthesis of concepts that are useful to cancer immunologists and pharmacologists, who tend to work in disparate fields with little cross-communication* Drs Prendergast and Jaffee are internationally recognized leaders in cancer biology and immunology who have created a unique synthesis of fundamental and applied concepts in this important new area of cancer research* Summarizes the latest insights into how immune escape defines an essential trait of cancer* Includes numerous illustrations including: how molecular-targeted therapeutic drugs or traditional chemotherapy can be combined with immunotherapy to improve anti-tumor efficacy; and how reversing immune suppression by the tumor can cause tumor regression

有重大增长在免疫抑制机制的理解以及它与癌症进展和治疗的关系。本书强调了免疫抑制的新原则，这些原则驱动着癌症，并提出了通过攻击这些原则来改进治疗方法的全新想法。随着工作已经牢固地确立了免疫逃逸是癌症的一个关键特征，最近的研究现在定义了肿瘤免疫抑制的具体机制。此外还展示了使用分子靶向疗法或传统化疗药物攻击肿瘤可以在预临床模型中产生强大的抗肿瘤效果。本书为基本、转化和临床癌症研究人员提供了一个有关癌症中免疫逃逸作为一个关键特征的基本概览，并探讨通过应用特定的免疫疗法与化学疗法相结合来攻击这一特征可能如何显著改善晚期疾病的治疗情况。* 提供了对有用的概念的综合，这些概念适用于癌症免疫学家和药理学家，他们通常在不同的领域工作且很少有交流* Dr Prendergast 和 Jaffee 是国际上公认的癌症生物学和免疫学领军人物，他们在这个重要领域的新研究中创建了一个独特的基本与应用概念的合成* 总结了如何免疫逃逸定义癌症的重要特征的最新见解* 包括许多插图，包括：说明分子靶向治疗药物或传统化疗药物如何与其他免疫疗法结合以提高抗肿瘤效果；以及逆转肿瘤免疫抑制是如何导致肿瘤消退的。

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