造血干细胞：组织发育和再生医学的基石

English | 2024 | ISBN-10: 9819974704 | 225 pages| Epub PDF (True) | 13 MB

This book renders a comprehensive understanding of hematopoietic stem cells (HSCs) from their embryonic development through adult maintenance to aging, in the studies conducted in zebrafish and mammals. Hematopoiesis provides a paradigm for understanding the development, maintenance, regeneration, aging and malignant transformation of mammalian organs. Sitting at the apex of the hematopoiesis hierarchy tree, HSCs orchestrate their proliferation, self-renewal, and differentiation to produce all the blood cell lineages throughout life, which represents the best example for somatic stem cell studies. In this book, key regulatory mechanisms for HSC self-renewal and differentiation are overviewed in an array of fields including epigenetics, metabolism and microenvironment regulation. It also highlights the HSC heterogeneity and clonal dynamics from the recent advanced single-cell technologies. This book elaborates on the research history of HSC studies and reveals how the insights from HSC studies shed light on their clinic application. It presents great value from the bench to the clinic.

这本书涵盖了造血干细胞（HSCs）从胚胎发育到成年维持直至衰老的研究，涉及斑马鱼和哺乳动物。造血分化为理解哺乳动物器官的发育、维护、再生、衰老以及恶性转化提供了范式。作为造血分化的顶点，HSC们调控其增殖、自我更新及分化，以产生他们一生中的所有血液谱系，这代表了对体细胞干细胞研究的最好例证。在本书中，从各种领域如表观遗传学、代谢和微环境调控等概述了调控HSC自更新与分化的关键机制。同时，它也强调了单细胞先进技术带来的HSC异质性和克隆动态的研究成果。书中详细阐述了HSC研究的历史，并揭示了这些发现如何为临床应用提供启示。本书从实验室到临床具有极高的价值。

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