《系统医学：生理回路与疾病的动力学（ Chapman & Hall/CRC 计算生物学系列）》

English | December 15, 2023 | ISBN: 1032412283, 1032411856 | 256 pages | PDF + EPUB | 21 + 14 MB

Why do we get certain diseases, whereas other diseases do not exist?

In this book, Alon, one of the founders of systems biology, builds a foundation for systems medicine.

Starting from basic laws, the book derives why physiological circuits are built the way they are. The circuits have fragilities that explain specific diseases and offer new strategies to treat them.

By the end, the reader will be able to use simple and powerful mathematical models to describe physiological circuits. The book explores, in three parts, hormone circuits, immune circuits, and aging and age-related disease. It culminates in a periodic table of diseases.

Alon writes in a style accessible to a broad range of readers - undergraduates, graduates, or researchers from computational or biological backgrounds. The level of math is friendly and the math can even be bypassed altogether. For instructors and readers who want to go deeper, the book includes dozens of exercises that have been rigorously tested in the classroom

为什么我们会患上某些疾病，而其他疾病却不存在？ 在这本书中，阿隆作为系统生物学的创始人之一，建立了系统医学的基础。 从基本定律出发，这本书推导出了生理电路是如何构建的原因。这些电路存在脆弱性，并解释了特定疾病的产生，同时提出了新的治疗方法策略。 到最后，读者将能够使用简单且强大的数学模型来描述生理电路。本书以三部分的内容探讨激素电路、免疫电路以及衰老与相关疾病。最后汇聚成一个疾病周期表。 阿隆的写作风格对广泛的读者群体都易于理解——无论是本科生、研究生还是来自计算或生物背景的研究人员。数学难度适中，甚至可以完全跳过数学而不影响阅读体验。对于想要深入了解内容的教师和读者，本书还包括了成百上千道经过严格课堂测试的练习题。

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