纳米药物递送技术在癌症治疗中的原理与实践
This book discusses the various modes and methods of nano-based drug delivery in different types of cancers such as colon, breast, cervical, ovarian, and lung cancer. It reviews the significance of nano drug delivery in cancer therapy, the application of nanoparticles in overcoming drug resistance, targeted therapy, and immunotherapy. The book also covers topics related to the synthesis of different types, shapes, and sizes of nanocarriers using synthetic and biological approaches. Further, a chapter explores the synthesis of nanocarriers loaded with anti-cancer drugs by using functionalization or conjugations and encapsulation methods. The book also examines the nanocarriers as delivery vehicles for chemotherapeutic agents against cancers using in vitro and animal models of cancers, preclinical trials for efficacy, and safety profiling of nanocarriers. Finally, future trends and innovation in nano drug delivery for cancer therapy, application of siRNA (nanoparticle-based RNA) therapy, ultrasound-linked nano-cancer therapeutics, and application of exosome-based cancer therapy topics are discussed. Towards the end, the book examines the limitations of nanocarriers, including the cell and tissue toxicity, genotoxicity, and scale-up of nanomaterials, health and environmental hazards associated with nanoformulation synthesis, respiratory diseases, government regulations, and ethical issues.
这本书讨论了各种纳米基药物输送方式和方法在结肠癌、乳腺癌、宫颈癌、卵巢癌和肺癌等不同类型的癌症中的应用。它回顾了纳米药物输送在癌症治疗中的意义，以及纳米颗粒的应用来克服耐药性、靶向疗法和免疫疗法。该书还涵盖了使用合成和生物方法制备不同类型、形状和大小的纳米载体的相关主题。此外，一章探索了通过功能化或共价连接和封装方法装载抗癌药物的纳米载体的合成。这本书还用体外和癌症动物模型对癌症化疗剂的纳米载体制输送载体进行评估，以及针对有效性与安全性的人体前临床试验。最后，书中讨论了用于癌症治疗的纳米药物递送的发展趋势、siRNA（基于纳米粒子的RNA）疗法的应用、超声辅助纳米癌症疗法以及基于外泌体的癌症疗法的应用。在书的末尾，该书考察了纳米载体的局限性，包括细胞和组织毒性、致突变性和纳米材料放大带来的健康与环境危害、纳米制剂合成相关的呼吸疾病、政府法规以及伦理问题。
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