RNA 基本的机制在癌症中

English | 2023 | ISBN: 9811248656 | 513 pages | True PDF EPUB | 55.14 MB

The roles of gene transcription in cancer have long been appreciated. However, posttranscriptional processes also contribute significantly to alterations in gene expression that lead to tumor initiation, formation, and progression.We have known for decades that alterations in the expression of key genes, such as those involved in cell proliferation, signaling, apoptosis, and immune responses, are major molecular events in cancer. This book presents our current understanding of selected posttranscriptional control mechanisms and the RNAs that they regulate. Each chapter provides an overview of a specific RNA-directed regulatory system and the RNA/protein factors involved, then discusses major findings in the field and their relationships to the development and/or treatment of cancer and associated diseases. Future questions serve to address 'where do we go from here' and stimulate the reader's thinking about these important problems.This compendium of chapters from experts in the field is essential reading for anyone interested in the myriad ways that RNAs contribute to tumorigenesis: from graduate students, researchers, and clinical scientists interested in mRNA processing and translation, RNA-binding proteins that promote turnover/stability of specific mRNAs, how small noncoding RNAs control inflammation and signaling, roles of the epitranscriptome, and future and emerging RNA-based, anti-tumor therapeutics.

基因转录在癌症中的作用一直被广泛认识。然而，后转录过程也显著地对导致肿瘤发生、发展和进展的基因表达改变做出了贡献。我们长期以来都知道，如细胞增殖、信号传导、凋亡和免疫反应等关键基因的表达变化是癌症中主要的分子事件。这本书介绍了我们对选定的后转录调控机制及其调节的RNA当前理解。每章都概述了一个特定的RNA导向调控系统以及它们涉及的RNA/蛋白质因素，然后讨论了该领域的主要发现及其与癌症及相关疾病的发生和发展或治疗的关系。未来的问题将用于回答“我们现在应该如何做”并刺激读者思考这些重要问题。这一章节集合是该领域的专家们的必备阅读材料，对于任何对RNA如何在肿瘤发生中发挥作用感兴趣的研究生、研究人员和临床科学家而言都是如此：从mRNA加工与翻译、促进特定mRNA降解/稳定性的RNA结合蛋白的作用、小非编码RNA调控炎症及信号传导的角色、表观转录组的作用，以及未来和新兴的基于RNA的抗肿瘤治疗方法。

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