阿尔茨海默病中的性别和性别差异

English | ISBN: 0128193441 | 512 pages | PDF | 2021 | 28.74 MB

Sex and Gender Differences in Alzheimer’s Disease: The Women’s Brain Project offers for the first time a critical overview of the evidence documenting sex and gender differences in Alzheimer’s disease neurobiology, biomarkers, clinical presentation, treatment, clinical trials and their outcomes, and socioeconomic impact on both patients and caregivers. This knowledge is crucial for clinical development, digital health solutions, as well as social and psychological support to Alzheimer’s disease families, in the frame of a precision medicine approach to Alzheimer’s disease. This book brings together up-to-date findings from a variety of experts, covering basic neuroscience, epidemiology, diagnosis, treatment, clinical trials development, socioeconomic factors, and psychosocial support. Alzheimer’s disease, the most common form of dementia, remains an unmet medical need for the planet. Wide interpersonal variability in disease onset, presentation, and biomarker profile make Alzheimer’s a clinical challenge to neuroscientists, clinicians, and drug developers alike, resulting in huge management costs for health systems and society. Not only do women represent the majority of Alzheimer’s disease patients, but they also represent two-thirds of caregivers. Understanding sex and gender differences in Alzheimer’s disease will lead to novel insights into disease mechanisms, and will be crucial for personalized disease management strategies and solutions, involving both the patient and their family.

女性大脑项目首次为阿尔茨海默病提供了有关该疾病神经生物学、生物标志物、临床表现、治疗、临床试验及其结果，以及对患者和护理人员的社会经济影响的证据概览。这些知识对于在精准医疗框架下的阿尔茨海默病临床开发、数字健康解决方案以及社会和心理支持至关重要。这本书汇集了各种专家的最新研究成果，涵盖了基本神经科学、流行病学、诊断、治疗、临床试验开发、经济社会因素及心理社会支持等领域。阿尔茨海默病是最常见的痴呆类型之一，至今仍未能得到全球医学界的满足。疾病发病时间、表现形式和生物标志物的变化使得阿尔茨海默病成为神经科学家、临床医生和药物开发者面临的临床挑战，并导致健康系统和社会巨大的管理成本。不仅女性是阿尔茨海默病患者中的多数，而且她们占照顾者的大约三分之二。理解阿尔茨海默病中性别的差异将带来对该疾病的机制新见解，并对患者及家庭参与的个性化疾病管理和解决方案至关重要。

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