大环内酯类作为免疫调节剂

English | PDF EPUB (True) | 2024 | 286 Pages | ISBN : 3031428587 | 15.9 MB

For over 50 years, clinicians have known that macrolide antibiotics have effects on inflammation and the immune system that are not related to their antimicrobial properties. These immunomodulatory properties, best described for treating inflammatory airway diseases, protect the lung and the host and improve clinical status. This book summarizes our current knowledge regarding proposed mechanisms for these properties, established clinical results, and what the future may hold with emphasis on novel clinical applications and the fascinating development of non-antimicrobial macrolides with preserved and enhanced immunomodulatory properties.

在超过50年的临床实践中，人们已知大环内酯抗生素对炎症和免疫系统的影响与它们的抗菌特性无关。这些免疫调节性质主要应用于治疗呼吸道疾病，可保护肺部及宿主，并改善临床状况。 这本书总结了我们目前对于这些性质所提出的机制、确立的临床结果，以及未来可能的发展方向，重点在于新兴的临床应用以及保留并增强了免疫调节特性的非抗菌大环内酯药物的有趣发展。

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