Neuromuscular Therapeutics: 一个全面指南

English | 3 February 2024 | ISBN-10: 3031395573 | 849 pages| PDF (True) | 73 MB

This book is a comprehensive reference of the neuraxial route for the delivery of therapeutics. It reviews the historical evolution of this approach from its inception in the later 1800's to present day. This amply referenced text covers basic discussions of spinal anatomy, embryogenesis, neuraxial vascularity, cerebrospinal fluid flow dynamics and parenchymal molecule movement. The pharmacokinetic and pharmacodynamic properties of different intrathecal agents are explored in detail with particular reference to clinical correlates in pain and spasticity. Particular attention is paid to the issues relevant to preclinical models of intrathecal delivery and the assessment of spinal pathologies arising from acute and chronic intrathecal drug delivery. Chapters provide essential discussions of clinical aspects of patient care, including patient evaluation and screening, trialing and device management, troubleshooting problems and addressing complications, best practices, cost-effectiveness and future of the therapy.

这本书是对治疗输送途径的全面参考资料，重点在于脊髓给药路线。它回顾了这一方法从19世纪后期首次出现到现在的发展历史。本文包含有关脊椎解剖学、胚胎发育、脊髓血管分布、脑脊液流动动态和组织内分子移动的基本讨论，并详细探索不同鞘内药物的药代动力学和药效动力学特性，特别侧重于临床疼痛和痉挛的表现。特别关注预体外模型中鞘内给药的相关问题以及由于急性或慢性鞘内药物输送引起的脊髓病变评估问题。章节提供有关患者护理的临床讨论，包括患者的评估与筛选、试验及设备管理、解决故障及处理并发症、最佳实践、成本效益分析和治疗未来的详细内容。

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