重塑神经系统的电路：健康与疾病状态下轴突和树突的机制

English | 2024 | ISBN: 9781032632698 | 332 pages | True PDF | 36.22 MB

This book examines recent key findings on the mechanisms of axonal and dendritic remodeling in different model organisms. Each chapter is contributed by a panel of experts in their respective subfields of neurosciences, to provide and discuss the latest discoveries ranging from neuronal morphogenesis during development, experience-dependent structural plasticity, to neuronal degeneration, regeneration, and pathologies in neurological disorders.

The process of neuronal remodeling, specifically their axons and dendrites, is essential for the proper wiring of the nervous system during early development and continues during postnatal ages to shape the pattern of synaptic connections throughout the life of the organism, including humans. Over recent years, substantial progress has been made in our understanding of the cellular and molecular mechanisms that control neuronal remodeling. In addition, there is accumulating evidence demonstrating how the nervous system could remodel in response to injury and in pathological conditions.

Topics discussed in the book include

Axonal degeneration during development and in pathological or disease conditions Neuronal morphogenesis (axons and dendrites) Experience-dependent structural plasticity to synaptogenesis Dendrite degeneration and regeneration

这本书探讨了不同模式生物中轴突和树突重塑的最新关键发现。每一章都由各自神经科学领域专家组成的小组撰稿，以提供并讨论从发育过程中神经元形态发生、经历依赖性结构可塑性，到神经系统疾病中的神经元退化、再生以及病理状况下的证据。 神经元重塑的过程，特别是他们的轴突和树突，在神经系统早期发育中至关重要，并在出生后持续进行，以塑造整个生命过程中的突触连接模式，包括人类。近年来，在我们对控制神经元重塑的细胞和分子机制的理解方面取得了显著进步。此外，还积累了大量证据，表明神经系统能够应受伤和病理条件而重新组织。 本书讨论的主题包括 轴突在发育过程中以及病理或疾病条件下发生退化 神经元形态发生（轴突和树突） 经历依赖性结构可塑性直至突触形成 树突的退化与再生

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